Gene Expression Program for Histological Reconstruction : Fibrogenesis induced pericellular fibrosis in rat liver, suppressed metastasis in human carcinomas

维生素C增加酒精性大鼠纤维形成过程中profilin、胶原蛋白和弹性蛋白的基因表达。模糊集合混沌算法（FSCA）使组织学调控成为可能，如调控分子的模糊ON/OFF重复。通过Pro、Gly和Cys的蛋白表达程序，VC、VB 1、Ca^<2+>诱导的纤维化得到加强。进行蛋白表达编程以通过靶向胶原中的特异性蛋白来减少来自t-RNA补充的核糖体上的翻译空转。对于基因表达式编程，我们使用的ON命令是1）通过抗坏血酸（VC）合成胶原蛋白，2）通过提供富含胶原蛋白的食物来增加胶原蛋白mRNA的翻译，3）通过将胶原蛋白与由钙激活的弹性蛋白结合来抑制转移的癌细胞，以及4）通过硫胺素（VB 1）、核黄素（VB 2）、吡哆醇（VB 6）、钴胺素（VB 12）在纤维形成过程中的作用。消除单个分子的供应构成了OFF命令。命令通过血流传输;它们被传递到感兴趣的区域是可能的，因为缓激肽、VEGF、前列环素、血小板活化因子等增加了转移癌细胞周围血管壁的渗透性。转移癌细胞周围的细胞因子和趋化因子用于告知转移癌细胞的位置的成纤维细胞。通过CT扫描证实成功包封，并通过患者生存能力判断治疗的有效性。GEP对纤维化的抑制作用在人体内可有效地包裹转移的癌细胞（92%）。一例硬癌胃患者携带印戒细胞被抑制7年。使用SF（清蒸小鱼）丰富Ala。丙氨酸增加了肝脏中的细胞周围纤维化，我们的程序图像显示了转移的癌细胞。

Vitamin C increased the gene expression of profilin, collagen and elastin during fibrogenesis in alcoholic rats. Fuzzy Set Chaos Algorithm (FSCA) made it possible to regulatehistology such as fuzzyON/OFF repeats of regulatormolecules. Fibrosis byVC, VB1, Ca^<2+>wasreinforced by protein expression programming by Pro, Gly and Cys. Protein expression programming was performed to reduce translational idling on ribosome from supplement of t-RNAs, by targeting specific protein in here collagens. For the Gene Expression Programming, the ON commands we used were 1) synthesize collagens by ascorbic acid (VC), 2) increase collagen mRNA translation by supplying collagen-enriched food, 3) envelopmetastasized cancer cells by combining collagen with elastinwhich is activated by calcium, and 4) proliferate fibroblastic cells by thiamin (VB1), riboflavin (VB2), pyridoxine (VB6), and cobalamin (VB12) during the fibrogenesis. Elimination of the supply of individual molecules constituted the OFF command. The commands were transmitted via the blood flow ; their delivery to the area of interest was possible because permeability of the walls of blood vessels around metastasized cancer cells is increased by bradykinin, VEGF, prostacyclin, platelet activating factor etc. Cytokines and chemokines around metastasized cancer cells served to inform fibroblasts of the location of metastasized cancer cells. Successful enveloping was confirmed by CT-scans and the effectiveness of the therapy was judged by patient viability. GEP for fibrogenesis appjied to envelope the metastasized cancer cells ran effectively in human (92%). A scirrhus stomach patient carrying signet ring cells have been suppressed for 7 years. Used SF (steamed small fishes) enriches Ala. Ala increased pericellular fibrosis in liver equivalents our program image of envelopment metastasized cancer cells.