Studies on ocular toxocariasis in new experimental animal model, Mongolian gerbil

虽然犬弓首线虫是人畜共患病的重要病原体，有向眼部迁移的趋势，但确切的迁移途径尚待确定。长爪沙鼠是人类弓形虫病的重要动物模型，本研究以长爪沙鼠为研究对象，探讨弓形虫向眼部的迁移途径。感染T.将犬直接接种到颅内区域。56.3%的病例有出血性病灶或出血性幼虫。组织病理学观察，接种后6天，在沙鼠视神经中观察到一只幼虫，在视网膜出血的沙鼠视交叉中观察到两只幼虫。这些结果表明T.犬通过视神经从大脑迁移到眼睛。考虑到这些数据以及口服给药沙鼠和颅内注射沙鼠之间幼虫外观的多样性，在向视网膜的迁移中有两个阶段：血原性早期阶段和视神经途径晚期阶段。

Although Toxocara canis, an important pathogen of zoonosis, tends to migrate to the eye, the precise migratory route has yet to be determined. Mongolian gerbils, Meriones unguiculatus, known as a useful animal model for human toxocariasis, were used to investigate the migration route toward the eyes. Infective larvae of T. canis were directly inoculated into the intracranial region. The hemorrhagic lesions or larvae were observed in 56.3% of cases. Histopathologically, a larva was observed in the optic nerve of gerbils 6 days after inoculation and two larvae were found in the optic chiasma in the gerbils having a hemorrhage in the retina. These results indicate that T. canis migrates from the brain to the eye through the optic nerve. Considering these data and the diversity of the appearance of larvae between the oral-administrated gerbils and the intracranial-injected gerbils, there are two phases in the migration to the retina : a hematogenous early phase and an optic nerve route late phase.