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Studies on ocular toxocariasis in new experimental animal model, Mongolian gerbil

新实验动物模型沙鼠眼弓蛔虫病的研究

基本信息

批准号：
11670240
负责人：
AKAO Nobuaki
金额：
$ 2.24万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670240/
关键词：
Toxocara canis Toxocara cati ocular toxocarias larva migrans Mongolian gerbil トキソカラ症

项目摘要

Although Toxocara canis, an important pathogen of zoonosis, tends to migrate to the eye, the precise migratory route has yet to be determined. Mongolian gerbils, Meriones unguiculatus, known as a useful animal model for human toxocariasis, were used to investigate the migration route toward the eyes. Infective larvae of T. canis were directly inoculated into the intracranial region. The hemorrhagic lesions or larvae were observed in 56.3% of cases. Histopathologically, a larva was observed in the optic nerve of gerbils 6 days after inoculation and two larvae were found in the optic chiasma in the gerbils having a hemorrhage in the retina. These results indicate that T. canis migrates from the brain to the eye through the optic nerve. Considering these data and the diversity of the appearance of larvae between the oral-administrated gerbils and the intracranial-injected gerbils, there are two phases in the migration to the retina : a hematogenous early phase and an optic nerve route late phase.

虽然犬弓形虫是人畜共患病的重要病原体，但其迁移的确切路线尚未确定。长爪沙鼠被认为是人类弓形虫病的有用动物模型，它被用来研究向眼睛的迁移路线。将犬弓形虫感染幼虫直接接种于颅内。出血性病变或幼虫占56.3%。组织病理学观察，沙土鼠视网膜出血后第6天视神经内可见1条幼虫，视交叉内可见2条幼虫。这些结果表明，犬毛滴虫通过视神经从大脑迁移到眼睛。考虑到这些数据以及口服沙土鼠和脑内注射沙土鼠幼虫形态的差异，沙土鼠向视网膜的迁移分为两个阶段：血源性早期和视神经通路晚期。