Studies on the interrelation among cytokines, chemokines and leukotrienes in airway inflammation.
气道炎症中细胞因子、趋化因子和白三烯之间相互关系的研究。
基本信息
- 批准号:11670578
- 负责人:
- 金额:$ 0.64万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:1999
- 资助国家:日本
- 起止时间:1999 至 2001
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
(Otgective) It is not known how the interrelation among cytokines, chemokines and leukotrienes, which are known to be associated with asthma, is modified during the clinical status of asthmatic patients. We investigated this interrelation to clarify the association of clinical features with airway inflammation, which frequently accompanies IgE production and the infiltration of eosinophils.(Results) We investigated whether there was association between asthma, and aging, IgE-mediafed allergy or bronchial hyperresponsiveness. We found that IgE-mediated allergy was relatively low in aged, asthmatic patients and that the bronchial hyperresponsiveness was associated with the IgE-mediated response and the ages of asthmatic onsets. Next we examined the production of leukotriene (LT) B4 (LTB4) and LTC4 by peripheral blood leukocytes obtained from asthmatic patients and found that there was correlation between their production, and asthmatic attack or bronchial hyperresponsiveness. Furthermore, in patients with chronic obstructive pulmonary diseases (COPD), which shows airway inflammation, their clinical status was suggested to be associated with the production of LTB4 and LTC4. We also showed that the production of LTC4 in COPD patients was associated with the IgE-mediated allergy.We noticed that the production of LTC4 tended to enhance during asthmatic attack as compared with its production during clinically controlled period. In addition, we showed that ECP and IL-5 in sputa and sera also tended to be elevated, whereas the prominent change of IL-4 levels was not recognized. The production of IL-5 by the peripheral blood mononuclear cells of asthmatic patients was also shown to be elevated slightly.These findings indicated that the airway inflammation during asthma was closely associated with the aging, IgE-mediated response and production of leukotrienes as well as cytokines, especially IL-5.
(目的)已知与哮喘相关的细胞因子、趋化因子和白三烯之间的相互关系在哮喘患者的临床状态中是如何改变的,目前尚不清楚。我们研究了这种相互关系,以阐明临床特征与气道炎症的关系,气道炎症经常伴随着IgE的产生和嗜酸性粒细胞的浸润。(结果)我们调查了哮喘与衰老、ige介导的过敏或支气管高反应性之间是否存在关联。我们发现ige介导的过敏在老年哮喘患者中相对较低,支气管高反应性与ige介导的反应和哮喘发病年龄有关。接下来,我们检测了哮喘患者外周血白细胞产生的白三烯(LT) B4 (LTB4)和LTC4,发现它们的产生与哮喘发作或支气管高反应性之间存在相关性。此外,在表现为气道炎症的慢性阻塞性肺疾病(COPD)患者中,他们的临床状态可能与LTB4和LTC4的产生有关。我们还发现慢性阻塞性肺病患者LTC4的产生与ige介导的过敏有关。我们注意到,与临床控制期相比,哮喘发作期间LTC4的产生有增加的趋势。此外,我们发现痰液和血清中ECP和IL-5也有升高的趋势,而IL-4水平的显著变化未被发现。哮喘患者外周血单个核细胞IL-5的产生也略有升高。这些发现表明哮喘气道炎症与衰老、ige介导的反应以及白三烯和细胞因子特别是IL-5的产生密切相关。
项目成果
期刊论文数量(17)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Mitsunobu F. et al.: "IgE-mediated and age-related bronchial hyper-responsiveness in patients with asthma. Relationship to family history of the disease"Age and Ageing. 29. 215-220 (2000)
Mitsunobu F. 等人:“哮喘患者中 IgE 介导的和与年龄相关的支气管高反应性。与疾病家族史的关系”年龄和衰老。
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- 影响因子:0
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Mitsunobu F. et al.: "Enhanced production of leukotrienes by peripheral leukocytes and specific IgE antibodies in patients with chronic obstructive pulmonary disease."J. Allergy and Clinical Immunology. 29. 492-498 (2001)
Mitsunobu F. 等人:“慢性阻塞性肺病患者外周白细胞和特异性 IgE 抗体产生的白三烯增强。”J.
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- 影响因子:0
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Mitsunobu F. et al.: "Enhanced peripheral leukocyte leukotriene production and bronchial hyperresponsivenness in asthmatics."European Respiratory Journal. 16 (3). 504-508 (2000)
Mitsunobu F. 等人:“增强外周白细胞白三烯的产生和哮喘患者的支气管高反应性。”欧洲呼吸杂志。
- DOI:
- 发表时间:
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- 影响因子:0
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Mitsunobu F. et al.: "Enhanced peripheral leukotriene production and bronchial hyperresponsiveness In asthmatics"European Respiratory journal. 16(3). 504-508 (2000)
Mitsunobu F.等人:“哮喘患者中外周白三烯的产生和支气管高反应性的增强”欧洲呼吸杂志。
- DOI:
- 发表时间:
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- 影响因子:0
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- 通讯作者:
Mitsunobu F. et al.: "Enhanced production of leukotrienes by peripheral leukocytes and specific IgE antibodies In patients with chronic obstructive pulmonary disease."J.Allergy and Clinical Immunology. 29(in press). (2001)
Mitsunobu F. 等人:“慢性阻塞性肺病患者外周白细胞和特异性 IgE 抗体增强白三烯的产生。”J.过敏与临床免疫学。
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MITSUNOBU Fumihiro其他文献
MITSUNOBU Fumihiro的其他文献
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{{ truncateString('MITSUNOBU Fumihiro', 18)}}的其他基金
Study on the effects of thermal therapy in respiratory rehabilitation
热疗在呼吸康复中的作用研究
- 批准号:
18500404 - 财政年份:2006
- 资助金额:
$ 0.64万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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