Pathophysiology of specific bronchial hyperresponsiveness

特定支气管高反应性的病理生理学

• 批准号: 07670662
• 负责人: FUJIMURA Masaki
• 金额: $ 1.6万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670662/
• 关键词: Specific bronchial hyperresponsiveness; Alcohol-induced asthma; ultrasonically nebulized distillled water; beta-blockers; Autonomic nerve system; Neuropeptides; Lipid mediators; Guinea pigs; アルコール誘発気道収縮; 交感神経遮断薬誘発気管支収縮; 蒸留水吸入誘発気管支収縮; 即時型アレルギー反応

1. Alcohol-induced bronchoconstriction in guinea pigs(1) Acetaldehyde, a metabolite of ethanol, causes bronchoconstriction but ethanol does not.(2) The acetaldehyde-induced bronchoconstriction is mediated via histamine release.(3) A low dose of acetaldehyde, which does not cause bronchoconstriction, enhances non-specific bronchial responsiveness.(4) Thromboxane A2 is involved in the acetaldehyde-induced non-specific bronchial hyperresponsiveness.2. A guinea big model of propranolol-induced bronchoconstriction and the role of autonomic nerve system, chemical mediators and neuropeptides(1) An inhalation of propranolo causes bronchoconstriction when it is inhaled 20 minutes after an aerosolized antigen provocation in passively sensitized guinea pigs.This is the first animal model or propranolol-induced bronchoconstriction.(2) Parasympathctic or alpha-adrenergic nerve activity is not involved in this response.(3) Ncuropeptides such as substance P and neurokinin A do not take a part in this … More response.(4) Lipid mediators, especially thromboxane A2, have an important role in this response.3. A guinea-pig model of untrasonically nebulized distillled water (UNDW) -induced bronchoconstriction and the role of autonomic nerve system, chemical mediators and neuropeptides(1) An inhalation of UNDW produces acute bronchoconstriction when it is inhaled 20 mimutes after an aerosolized antigen provocation in passively sensitized guinea pigs.This is the first animal model of UNDW-induced bronchoconstriction.(2) Parasympathetic nerve activity is not involved in this response.(3) Histamine and substance P,but not neurokinin A,take a large part in this response.(4) Thromboxane A2 does not have a role in this response.4. ConclusionForm these results, it is suggested that allergic airway response, or allergic airway inflammatory process, is important in development of specific bronchial responsiveness. Furthermore, the mechanism of specific bronchial hyperresponsiveness may be different each other, suggesting heterogeneity of contributing factors between several specific bronchial hyperresponsiveness in asthma. Less

1。酒精诱导的豚鼠的支气管收缩（1）乙醇是乙醇的代谢产物，会导致支气管收缩，但乙醇却没有。（2）乙醛诱导的支气管诱导的支气管诱导的支气管收缩是通过组胺释放介导的。 （4）血栓烷A2参与乙醛诱导的非特异性支气管性过度反应。2。豚鼠的主要模型的大型模型是丙糖醇诱导的支气管收缩以及自主神经系统，化学介质和神经肽的作用（1）当在刺激性敏感的吉尼亚猪中，在繁星化的抗原造成的抗原抗原后，将普萘洛尔吸入propranolol会导致支气管固定在20分钟后。副交感神经或α-肾上腺素神经活性与这种反应无关。（3）诸如PESSS P和NEUROKININ A之类的Ncuropepides不参与此……更多的反应。（4）脂质介质，尤其是势盒A2，在此反应中具有重要作用。33。豚鼠的无可转移蒸馏水（UPW）诱导的支气管收缩以及自主神经系统的作用以及自主神经系统，化学介质和神经肽的作用（1）在急性支气管中，当急性支气管集成20 Mimimutes时，将急性支气管化的动物促进式拟南芥质量构建在急诊素中时，对急性支气管收缩产生了急性支气管。 （2）副交感神经活性与这种反应无关。（3）组胺和物质P，但不参与神经蛋白A，在此反应中很大一部分。（4）血栓烷A2在此反应中没有作用。4。结论这些结果，建议过敏性气道反应或过敏性气道炎症过程对于开发特定的支气管反应性很重要。此外，特异性支气管高反应性的机制可能彼此不同，表明哮喘中几种特定支气管性过度反应性之间有因素的异质性。较少的

项目成果

Fujimura M,et al.: "Role of sensory neuropeptides in post-allergic propranolol-induced bronchoconstriction in guinea pigs in vivo." Clin Exp Allergy. 26(12). 1428-1435 (1996)

Fujimura M 等人：“感觉神经肽在豚鼠体内过敏后普萘洛尔诱导的支气管收缩中的作用。”

Myou S,Fujimura M: "Inhibitory effect of terfenadine, a selective H1-histamine antagonist, on alcoholic beverage-induced bronchoconstriction in asthmatic patients." Eur Respir J. 8. 619-623 (1995)

Myou S，Fujimura M：“特非那丁（一种选择性 H1-组胺拮抗剂）对哮喘患者酒精饮料引起的支气管收缩的抑制作用。”

Myou S,Fujimura M,Nishi K,Ohka T,Matsuda T.: "Inhibitory effect of terfenadine, a selective H1-histamine antagonist, on alcoholic beverage-induced bronchoconstriction in asthmatic patients." Eur Respir J. 8 (4). 619-623 (1995)

Myou S、Fujimura M、Nishi K、Ohka T、Matsuda T.：“特非那定（一种选择性 H1-组胺拮抗剂）对哮喘患者酒精饮料引起的支气管收缩的抑制作用。”

Fujimura M,Amemiya T,Myou S,Mizuguchi M,Matsuda T.: "A guinea-pig model of ultrasonically nebulized distillled water-induced bronchoconstriction." Eur Respir J. 10. 2237-2242 (1997)

Fujimura M、Amemiya T、Myou S、Mizuguchi M、Matsuda T.：“超声波雾化蒸馏水诱导支气管收缩的豚鼠模型。”

Songur N,Fujimura M,Mizuhashi K,Saito M,Matsuda T.: "Effect of AL-3264 on propranolol-induced bronchoconstriction in guinea pigs." J Lipid Mediators Cell Signaling. 11 (2). 175-185 (1995)

Songur N、Fujimura M、Mizuhashi K、Saito M、Matsuda T.：“AL-3264 对豚鼠心得安引起的支气管收缩的影响。”