A study of interstitial pneumonia with HCV transgenic mouse

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Pathogenesis of IIP (idiopathic interstitial pneumonia) is still unclear despite of its poor prognosis. We hypothesized that HCV (hepatitis C virus), which has been recognized as one of major pathogen of fibrous change in liver, may play a role in IIP.First, we confirmed significantly high population of patients with IIP have antibody against HCV and patients with IIP are more frequently positive in RT-PCR to HCV as compared to controls. In this study we investigated the role of this virus in IIP with HCV transgenic mouse by our murine model for IIP.HCV transgenic mouse has significantly more lymphocytes in BALF as compared to wild type mouse in natural course. Furthermore, at the point of 2 weeks after silica particulate instillation, HCV transgenic mouse had much more doses of hydroxyproline (wild : wild+silica : HCVenv : HCVenv+silica = 150±45 : 350±32 : 295±40 : 438±48) and higher pathological scores for IIP as compared to those of wild type mouse with same treatment. These findings proposed that HCV might promote the progression of fibrous changes in lung in response to silica.