THE ASSOCIATION BETWEEN IMPULSIVENESS/AGGRESSIVENESS AND SEROTONIN RELATED GENE POLYMORPHISM

冲动/攻击性与血清素相关基因多态性的关联

• 批准号: 11670935
• 负责人: SAKADO Kaoru
• 金额: $ 2.24万
• 依托单位: NIIGATA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670935/
• 关键词: impulsiveness; aggressiveness; serotonin; gene; polymorphism; association study; 遺伝子多型

Firstly, we developed the Japanese version of the Barratt Impulsiveness Scale, 11th version(BIS-11)since there has been no instrument for assessing impulsiveness/ aggressiveness in Japan. After translating the BIS-11 into Japanese, we investigated reliability and validity in student's(N=34)and worker's(N=416)samples. To test test-retest reliability, intraclass coefficients by analysis of variance between test and retest were calculated .Internal consistency was examined by calculating Cronbach's alpha. To see the factor validity, we examined whether or not three-factor model proposed by a previous report fit the data, using confirmatory factor analysis. The results showed that the Japanese version of the BIS-11 had excellent test-retest reliability and acceptable internal consistency reliability. The Japanese version was judged to have similar factor structure to the original one. Second, we examine the distribution of polymorphism in the promoter region of serotonin transporter gene, using about 150 blood samples. As found in previous studies, our results suggested that Japanese subjects were more likely to have the tandem repeat of short type than that of long type.

首先，我们开发了日本版的Barratt冲动量表，第11版（BIS-11），因为日本还没有评估冲动/攻击性的工具。在将BIS-11翻译成日语后，我们在学生（N=34）和工人（N=416）样本中调查了信度和效度。采用方差分析计算组内系数，计算Cronbach’s α检验内部一致性，检验重测信度。为了了解因素的有效性，我们使用验证性因素分析来检验先前报告提出的三因素模型是否适合数据。结果表明，日文版BIS-11具有良好的重测信度和可接受的内部一致性信度。日本版本被认为具有与原始版本相似的因素结构。其次，我们使用约150份血液样本，检测了5-羟色胺转运体基因启动子区的多态性分布。与以往的研究一样，我们的研究结果表明，日本人的串联重复序列更可能是短型而不是长型。

项目成果

Someya,T,Sakado,K他,5名: "The Japanese version of the Barratt Impulsiveness Scale,11th version (BIS-11) : its reliability and validity"Psychiatry and Clinical Neuroscience. (印刷中).

Someya, T、Sakado, K 和其他 5 人：“日本版 Barratt 冲动量表，第 11 版 (BIS-11)：其可靠性和有效性”精神病学和临床神经科学（正在出版）。

Someya T., Sakado K., Seki T., Kojima M., Reist, C., Tang S.W., Takahashi, S.: "The Japanese version of the Barratt Impulsiveness Scale, 11th version(BIS-11) : its reliability and validity."Psychiatry and Clinical Neuroscience. (in print).

Someya T.、Sakado K.、Seki T.、Kojima M.、Reist, C.、Tang S.W.、Takahashi, S.：“日本版 Barratt 冲动量表，第 11 版（BIS-11）：其可靠性和