THE ASSOCIATION BETWEEN IMPULSIVENESS/AGGRESSIVENESS AND SEROTONIN RELATED GENE POLYMORPHISM

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Firstly, we developed the Japanese version of the Barratt Impulsiveness Scale, 11th version(BIS-11)since there has been no instrument for assessing impulsiveness/ aggressiveness in Japan. After translating the BIS-11 into Japanese, we investigated reliability and validity in student's(N=34)and worker's(N=416)samples. To test test-retest reliability, intraclass coefficients by analysis of variance between test and retest were calculated .Internal consistency was examined by calculating Cronbach's alpha. To see the factor validity, we examined whether or not three-factor model proposed by a previous report fit the data, using confirmatory factor analysis. The results showed that the Japanese version of the BIS-11 had excellent test-retest reliability and acceptable internal consistency reliability. The Japanese version was judged to have similar factor structure to the original one. Second, we examine the distribution of polymorphism in the promoter region of serotonin transporter gene, using about 150 blood samples. As found in previous studies, our results suggested that Japanese subjects were more likely to have the tandem repeat of short type than that of long type.