Novel modalities for prostate cancer screening: mast cells as predictors of disease, disease aggressiveness and marks of disease disparity
前列腺癌筛查的新方法:肥大细胞作为疾病、疾病侵袭性和疾病差异标志的预测因子
基本信息
- 批准号:10650620
- 负责人:
- 金额:$ 20.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-06-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectAfrican AmericanAgeAgingAreaBenignBiologicalBiological MarkersBiopsyBiopsy SpecimenCancer PatientCaregiversCell AggregationCell CountCellsClinicCollectionComplexCore BiopsyDataData AnalysesDevelopmentDiagnosisDiagnosticDiseaseDisparityDoctor of MedicineEarly DiagnosisEndowmentEthnic PopulationEvaluationFacultyFeasibility StudiesFutureGene Expression ProfilingGenesGoalsGrantHealthHumanHypersensitivityImageImage AnalysisIncidenceLaboratoriesLesionMalignant NeoplasmsMalignant neoplasm of prostateMeasuresMedicalMethodsModalityMolecularMolecular ProfilingMorbidity - disease rateMusNatureNormal tissue morphologyOncogenicOncologistPatientsPhenotypePhysiciansPilot ProjectsPopulationPositioning AttributePredictive ValuePredispositionPreventionPropertyProstateProstaticProstatic TissueRaceResearchRiskSamplingScreening for Prostate CancerSiteSolid NeoplasmSourceSphingolipidsSurvey MethodologyTestingTissuesUnited StatesUrologyVariantbaby boomercancer diagnosiscancer health disparitycaucasian Americanclinically relevantclinically significantcomputerizedcost effectivedisease disparityfirst responderfunctional statushigh riskhuman tissueimaging modalityimprovedinnovationinsightinterestmast cellmembermenmortalitynoveloverexpressionprismaprostate biopsyprostate cancer riskquantitative imagingracial disparityracial populationscreeningsphingosine 1-phosphatesuccesstumorurologicvalidation studies
项目摘要
SUMMARY
Prostate cancer (PCa) is the second most common cancer in men in the United States. The absolute number
of men with PCa is projected to increase as a result of the ageing baby boomer population. However, the lack
of reliable biomarkers for PCa screening has led to decreased early detection, particularly for African American
(AA) men who have the highest PCa morbidity, metastatic risk and mortality rates than any other racial or
ethnic group in the US. When cancer is suspected, patients must undergo multiple needle core biopsies
because of the multifocal nature of PCa. Nonetheless, up to 34% of biopsied men are told they are cancer-free
when they are not, because the biopsies missed the cancer foci. Hence, it is critical to better define the
cellular and molecular features indicative of PCa development and risk for aggressive disease in benign
biopsies of PCa patients to improve diagnosis and screening. In this grant, we are proposing to explore a
variation on the concept of field effect in PCa, postulating that histopathologically benign looking prostate core
biopsies may in fact feature alterations indicative of PCa and of PCa aggressiveness present in the same
patient at another prostatic site, using age- and race-matched (AA and Caucasian Americans (CA)) sets of
samples (benign and cancer-bearing biopsies for each patient). Prostate-resident mast cells (MC) aggregate in
stromal, peritumoral and/or intratumoral areas but their clinical relevance remains controversial. Our preliminary
data suggests the usefulness of establishing MC profiles in benign prostatic tissues of PCa patients. The
objectives of this application are: to investigate MC functional profiles in benign human prostate tissues as
predictors of PCa aggressiveness and candidate functional biomarkers of PCa race disparity; to define and
validate a molecular signature indicative of PCa and PCa aggressiveness present in benign human prostate
biopsies and test its predictive value for PCa disparity and association to MC; and apply our new screening
modalities in clinics, contingent upon successful validation studies. We anticipate that our approach may
improve diagnosis and screening for high-risk PCa and position MC as potential drivers of PCa disparity.
总结
前列腺癌(PCa)是美国男性中第二常见的癌症。绝对数量
由于婴儿潮一代人口的老龄化,预计PCa男性的发病率将增加。但缺乏
PCa筛查的可靠生物标志物导致早期检测减少,特别是非洲裔美国人
(AA)与其他种族相比,男性具有最高的PCa发病率、转移风险和死亡率,
美国的种族。当怀疑癌症时,患者必须接受多针芯活检
因为前列腺癌的多灶性尽管如此,高达34%的活检男性被告知他们没有癌症
因为活组织检查遗漏了癌灶。因此,更好地定义
细胞和分子特征指示前列腺癌的发展和良性肿瘤中侵袭性疾病的风险
PCa患者的活检,以提高诊断和筛查。在这一补助金中,我们建议探索一种
PCa中场效应概念的变化,假设组织病理学上看起来良性的前列腺核心
活组织检查实际上可能具有指示PCa和PCa侵袭性的改变,
另一个前列腺部位的患者,使用年龄和种族匹配(AA和高加索美国人(CA))的
样本(每例患者的良性和癌症活检)。前列腺肥大细胞(MC)聚集在
间质、瘤周和/或瘤内区域,但其临床相关性仍有争议。我们的初步
数据提示在PCa患者的良性前列腺组织中建立MC谱的有用性。的
本申请的目的是:研究良性人前列腺组织中的MC功能谱,
PCa侵袭性的预测因子和PCa种族差异的候选功能性生物标志物;
验证指示存在于良性人前列腺中的PCa和PCa侵袭性的分子特征
活检并测试其对PCa差异的预测价值以及与MC的关联;并应用我们的新筛查方法
在诊所的模式,取决于成功的验证研究。我们预计,我们的方法可能
改善高风险前列腺癌诊断和筛查,并将MC定位为前列腺癌差异的潜在驱动因素。
项目成果
期刊论文数量(0)
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CAROLE A OSKERITZIAN其他文献
CAROLE A OSKERITZIAN的其他文献
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{{ truncateString('CAROLE A OSKERITZIAN', 18)}}的其他基金
Development of a noninvasive, rapid and affordable method for early detection of colorectal cancer
开发一种无创、快速且经济实惠的结直肠癌早期检测方法
- 批准号:
10044350 - 财政年份:2020
- 资助金额:
$ 20.9万 - 项目类别:
Development of a noninvasive, rapid and affordable method for early detection of colorectal cancer
开发一种无创、快速且经济实惠的结直肠癌早期检测方法
- 批准号:
10456820 - 财政年份:2020
- 资助金额:
$ 20.9万 - 项目类别:
Development of a noninvasive, rapid and affordable method for early detection of colorectal cancer
开发一种无创、快速且经济实惠的结直肠癌早期检测方法
- 批准号:
10174880 - 财政年份:2020
- 资助金额:
$ 20.9万 - 项目类别:
MicroRNAs in atopic dermatitis pathogenesis: a role for mast cell and sphingosine-1-phosphate?
MicroRNA 在特应性皮炎发病机制中:肥大细胞和 1-磷酸鞘氨醇的作用?
- 批准号:
9035633 - 财政年份:2016
- 资助金额:
$ 20.9万 - 项目类别:
48th Annual South Eastern Regional Lipid Conference (SERLC) Funding Support
第 48 届年度东南地区脂质会议 (SERLC) 资金支持
- 批准号:
8651999 - 财政年份:2013
- 资助金额:
$ 20.9万 - 项目类别:
Mast Cell S1P Receptor2 in the initiation and progression of chronic inflammation
肥大细胞S1P受体2在慢性炎症的发生和进展中的作用
- 批准号:
8295787 - 财政年份:2012
- 资助金额:
$ 20.9万 - 项目类别:
Mast Cell S1P Receptor2 in the initiation and progression of chronic inflammation
肥大细胞S1P受体2在慢性炎症的发生和进展中的作用
- 批准号:
8730283 - 财政年份:2012
- 资助金额:
$ 20.9万 - 项目类别:
Mast Cell S1P Receptor2 in the initiation and progression of chronic inflammation
肥大细胞S1P受体2在慢性炎症的发生和进展中的作用
- 批准号:
8681300 - 财政年份:2012
- 资助金额:
$ 20.9万 - 项目类别:
Mast Cell S1P Receptor2 in the initiation and progression of chronic inflammation
肥大细胞S1P受体2在慢性炎症的发生和进展中的作用
- 批准号:
8859955 - 财政年份:2012
- 资助金额:
$ 20.9万 - 项目类别:
Sphingosine-1-Phosphate, A Novel Mediator of Human Skin Mass Cell Functions
1-磷酸鞘氨醇,人类皮肤细胞功能的新型介质
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7147486 - 财政年份:2006
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$ 20.9万 - 项目类别:
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