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The fundamental study of biofeedback treatments using biological markers such as Event-related potentials (ERPs) and exploratory eye movements (EEMs) in schizophrenic patients

使用事件相关电位（ERP）和探索性眼球运动（EEM）等生物标志物对精神分裂症患者进行生物反馈治疗的基础研究

基本信息

批准号：
11670971
负责人：
MORITA Kiichiro
金额：
$ 1.98万
依托单位：
KURUME UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2002
项目状态：
已结题

项目摘要

In schizophrenic patients, event-related potentials (ERPs) and exploratory eye movements (EEMs) have been used as biological correlates of information processing. Previously, Morita, tile prinspal investigator in this study, investigated ERPs and EEMs during recover period in schizophrenic patients in comparison with these in healthy subjects. This study and compared the effects of facial affective stimuli on visual ERPs and EEMs using photographs of babies crying and smiling while recording autonomic vital markers such as ECG, skin conductance and heart rate to monitor the emotional responses. We reported that the P300 amplitude, area and eye movements became more similar to those of healthy subjects after recovery from illness. For example, the P300 amplitude and area while viewing photograph of a smiling baby were the same as these while viewing crying baby. However, the values while viewing smiling baby were smaller than these while viewing crying baby at clinical improving phase in the patients. These findings suggest that both the ERPs and EEMs evoked by these facial affect stimuli are useful biological state markers and may be useful as feed back during clinical treatment. However, the findings were insufficient to record the emotional effects reflected by ECG, skin conductance and heart rate during ERPs and EEMs recordings. Thus, we are currently trying to monitor the ERPs, EEMs and other markers using crying and laughing voices and pleasant and unpleasant odors. These additional stimuli caused larger emotional effects and changed several biological markers. The degree of emotional level induced by facial-affect recognition with voices and odors may vary more depending on the clinical state. The failure to accurately read nonverbal emotional cues may contribute to inappropriate social responses.

在精神分裂症患者中，事件相关电位（ERP）和探索性眼球运动（EEM）已被用作信息处理的生物相关性。此前，本研究的主要研究者 Morita 调查了精神分裂症患者恢复期的 ERP 和 EEM，并与健康受试者进行了比较。这项研究使用婴儿哭泣和微笑的照片，同时记录心电图、皮肤电导和心率等自主生命标记来监测情绪反应，比较了面部情感刺激对视觉 ERP 和 EEM 的影响。我们报告说，病愈后，P300 振幅、面积和眼球运动变得与健康受试者更加相似。例如，观看微笑婴儿的照片时的 P300 幅度和面积与观看哭泣的婴儿时的 P300 幅度和面积相同。然而，在临床改善阶段的患者中，观看微笑婴儿时的数值小于观看哭泣婴儿时的数值。这些发现表明，这些面部情感刺激引起的 ERP 和 EEM 都是有用的生物状态标记，并且可能在临床治疗期间作为反馈有用。然而，研究结果不足以记录 ERP 和 EEM 记录期间心电图、皮肤电导和心率所反映的情绪影响。因此，我们目前正在尝试使用哭声和笑声以及令人愉快和不愉快的气味来监测 ERP、EEM 和其他标记。这些额外的刺激引起了更大的情绪影响，并改变了一些生物标志物。通过声音和气味进行面部情感识别所诱发的情绪水平可能会根据临床状态而有所不同。无法准确解读非语言情感线索可能会导致不恰当的社交反应。