Trial of donor specific immunosuppression with BrdU using rat liver transplant model

使用大鼠肝移植模型检查了 BrdU 和 5FU 消除器官排斥的情况。 ACI大鼠肝脏原位移植到LEW大鼠体内。如果不进行治疗，接受者会在 11 天内死亡。静脉注射BrdU和5FU治疗后存活天数为17天。然而，通过腹腔内连续注射 BrdU 和 5FU 治疗，患者存活了 45 天。组织学结果显示治疗组没有出现排斥反应。另一方面，在未治疗组中，发现了严重的细胞浸润。

Abrogation of organ rejection by BrdU and 5FU was examined using rat liver transplant model. ACI rat liver was transplanted into LEW rat orthotopically. Without treatment the recipient was died within 11days. With the treatnent of intravenous injection of BrdU and 5FU surviva days was 17 days. However, with the treatment of intraperitoneal contimuous injection of BrdU and 5FU the recioent lived for 45 days. Histrogical findings revealed no rejection in the treatment group. On the other hand in the no treatment group, severe cell infiltration was recognized.