Trial of donor specific immunosuppression with BrdU using rat liver transplant model

使用大鼠肝移植模型进行 BrdU 供体特异性免疫抑制试验

• 批准号: 11671155
• 负责人: TERAMOTO Kenichi
• 金额: $ 0.96万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671155/
• 关键词: liver transplantation; organ rejection; bromodeoxyuridine; BrdU; 特異的免疫抑制

Abrogation of organ rejection by BrdU and 5FU was examined using rat liver transplant model. ACI rat liver was transplanted into LEW rat orthotopically. Without treatment the recipient was died within 11days. With the treatnent of intravenous injection of BrdU and 5FU surviva days was 17 days. However, with the treatment of intraperitoneal contimuous injection of BrdU and 5FU the recioent lived for 45 days. Histrogical findings revealed no rejection in the treatment group. On the other hand in the no treatment group, severe cell infiltration was recognized.

使用大鼠肝移植模型检查了BrdU和5 FU对器官排斥反应的消除。将ACI大鼠肝脏原位移植到LEW大鼠体内。未接受治疗，患者在11天内死亡。静脉注射BrdU和5FU治疗组生存期为17天。腹腔内连续注射BrdU和5FU，存活45天。组织学检查结果显示治疗组无排斥反应。另一方面，在未处理组中，识别到严重的细胞浸润。

项目成果

寺本研一 (Teramoto, et al): "Expression of tumor necrosis factor-α gene during allograft rejection"Liver. 19. 19-24 (1999)

Kenichi Teramoto (Teramoto 等人)：“同种异体移植排斥过程中肿瘤坏死因子-α 基因的表达”肝脏。19. 19-24 (1999)

寺本研一(Teramoto, et al): "Expression of tumor necrosis factor-α gene during allograft rejection"Liver. 19. 19-24 (1999)

Kenichi Teramoto (Teramoto 等人)：“同种异体移植排斥过程中肿瘤坏死因子-α 基因的表达”肝脏。19. 19-24 (1999)

Kenichi Teramoto, et al: "Expression of tumor necrotsis factor alpha gene during allograft rejection"LIVER. 19. 19-24 (1999)

Kenichi Teramoto 等人：“同种异体移植排斥过程中肿瘤坏死因子 α 基因的表达”肝脏。