Trial of donor specific immunosuppression with BrdU using rat liver transplant model

用大鼠肝移植模型观察BrdU和5-FU对器官排斥反应的抑制作用。将ACI大鼠肝脏原位移植到LEW大鼠体内。未接受治疗，患者在11天内死亡。静脉注射BrdU和5 FU治疗，生存期为17天。腹腔内连续注射BrdU和5 FU，存活45天。组织学检查结果显示治疗组无排斥反应。另一方面，在未处理组中，识别到严重的细胞浸润。

Abrogation of organ rejection by BrdU and 5FU was examined using rat liver transplant model. ACI rat liver was transplanted into LEW rat orthotopically. Without treatment the recipient was died within 11days. With the treatnent of intravenous injection of BrdU and 5FU surviva days was 17 days. However, with the treatment of intraperitoneal contimuous injection of BrdU and 5FU the recioent lived for 45 days. Histrogical findings revealed no rejection in the treatment group. On the other hand in the no treatment group, severe cell infiltration was recognized.