Photo-coagulation therapy for pial arteriovenous malformation and dural arteriovenous malformation.

光凝治疗软脑膜动静脉畸形和硬脑膜动静脉畸形。

• 批准号: 11671368
• 负责人: SATOH Koichi
• 金额: $ 1.79万
• 依托单位: University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671368/
• 关键词: endovascular treatment; photo-coagulation therapy; ultraviolet; rat; common carotid artery

The treatment of the brain and dural arteriovenous malformation, by operation, endovascular embolization or stereotactic irradiation is effective. However, treatment is difficult in the large lesions. In this basic research, we try to irradiate ultraviolet ray to the endothelium of the arteriovenous malformation. We using carotid artery of rats, after the cramp of carotid artery and we incised artery and exposure of endothelium. We irradiate Vilber Loumat 15W ultraviolet lamp (using the 3 types wavelength ; 365 nm, 312 nm, 254 mn) from 10 cm distance. Ultraviolet irradiation was carried out in the several time interval which was various from the distance. Though all carotid arteries incised part were sutured by the postirradiation using 10-0 nylon yarn, and the blood flow was resumed. Blood flow condition of the irradiation part minute was good. There is no significant change on the histological analysis of all carotid artery of the irradiation part. The occlusive reaction could not be detected by this method, therefor, it is necessary to establish the new method such as combined with photo sensitizer.In this study, we reported clinical cases of dural AVF with intracranial cerebellar hemorrhage.

手术、血管内栓塞或立体定向放射治疗是治疗脑动静脉畸形的有效方法。然而，治疗是困难的，在大病变。在本基础研究中，我们尝试用紫外线照射血管内皮细胞。采用大鼠颈总动脉，颈总动脉痉挛后，切开动脉，暴露内皮。我们照射Vilber Loumat 15 W紫外灯（使用3种波长; 365 nm，312 nm，254 nm）从10 cm的距离。紫外线照射在不同的时间间隔进行，这是不同的距离。所有颈动脉切段放射后用10-0尼龙线缝合，血流恢复。照射部位微循环良好。所有受照部位颈动脉组织学分析无明显变化。因此，有必要建立一种新的方法，如结合光敏剂的方法。本研究报告了硬脑膜动静脉瘘合并颅内小脑出血的临床病例。

项目成果

K.Satoh,J.Satomi,N.Nakajima,S.Matsubara,S.Nagahiro: "Cerebellar hemorrhage caused by dural arteriovenous fistula : a review of five cases"Journal of Neurosurgery. 94(in press). 422-426 (2001)

K.Satoh，J.Satomi，N.Nakajima，S.Matsubara，S.Nagahiro：“硬脑膜动静脉瘘引起的小脑出血：五例回顾”神经外科杂志。

Koichi Satoh, Junichiro Satomi, Norio Nakajima, Shunji Matsubara, Shinji Nagahiro.: "Cerebellar hemorrhage caused by dural arteriovenous fistula : a review of five cases."J.Neurosurg.. 94 (in press). 422-426 (2001)

Koichi Satoh，Junichiro Satomi，Norio Nakajima，Shunji Matsubara，Shinji Nagahiro.：“硬脑膜动静脉瘘引起的小脑出血：五例回顾。”J.Neurosurg.. 94（印刷中）。