Caveolin expression and androgen independent growth of prostate cancer

Caveolin 表达和前列腺癌的雄激素非依赖性生长

• 批准号: 11671555
• 负责人: TSUSHIMA Tomoyasu
• 金额: $ 1.41万
• 依托单位: OKAYAMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671555/
• 关键词: prostate cancer; caveolin; Careolin; アンドロゲン

In order to elucidate the clinical implication of caveolin to the androgen independent growth of the human prostate cancer, we have conducted this study. We detected the expression of caveolin in 64 cases of human prostate cancer tissue using immunohistochemical staining.1. Expression of caveolin in human prostate cancer tissue :Folmaline fixed paraffin embeded prostate cancer tissue were stained immunohistochemically by ABC method. In prostate cancer cell, caveolin was positively stained with diffuse or granular pattern.2. Correlation with histological grade :Although it is not statistically significant, high grade cancer tissue showed higher degree of positive staining.3. Correlation with clinical stage :Although it is not statistically significant, high stage cancer tissue showed higher positive staining. Analysis of the metastatic site such as lymph mode is indicated for further study.4. Correlation with prognosis :In order to elucidate the prognostic value of the caveolin expression, clincal survey of patients was performed. No statistically significant correlation was observed between clinical prognosis and caveolin expression.5. Correlation with the clinical response to anti-androgen therapyNo statistically significant correlation was observed between andreogen indpendent relapse and caveolin expression.

为了阐明小窝蛋白在人前列腺癌雄激素非依赖性生长中的临床意义，我们进行了这项研究。采用免疫组织化学方法检测前列腺癌组织中小窝蛋白的表达。小窝蛋白在人前列腺癌组织中的表达：采用ABC法对石蜡包埋的前列腺癌组织进行免疫组织化学染色。结论：1.在前列腺癌细胞中，小窝蛋白呈弥漫或颗粒状阳性染色。与组织学分级的相关性：虽然无统计学意义，但高级别癌组织阳性染色程度较高。与临床分期的相关性：虽然无统计学意义，但高分期癌组织阳性染色较高。对转移部位的分析，如淋巴方式等，有待进一步研究。与预后的相关性：为了阐明小窝蛋白表达的预后价值，我们对患者进行了临床调查。临床预后与小窝蛋白表达之间无统计学意义的相关性。雄激素依赖性复发与小窝蛋白表达之间无统计学意义的相关性。

项目成果

那須 保友: "前立腺癌に対する遺伝子治療-HSV-tk遺伝子を用いた自殺遺伝子治療-"医学のあゆみ. 192(2). 184-185 (1999)

Yasutomo Nasu：“前列腺癌的基因治疗 - 使用 HSV-tk 基因的自杀基因治疗”，医学史 192(2)。

那須 保友: "泌尿器腫瘍学入門"日本医学館. 17 (2000)

Nasu Yasutomo Nasu：“泌尿肿瘤学概论”日本医学博物馆17（2000）。

Y, Nasu: "Prostate Cancer Gene Therapy -Suicide Gene Therapy using HSV-tk gene-"IGAKUNOAYUMI. 192(2). 184-185 (1999)

Y，奈须：“前列腺癌基因治疗-使用HSV-tk基因的自杀基因治疗-”IGAKUNOAYUMI。

Y, Nasu: "Androgen dependent growth of the prostate cancer and caveolin"Urological Review. 3(3). 2-5 (2001)

Y，Nasu：“前列腺癌和小窝蛋白的雄激素依赖性生长”泌尿学评论。

那須保友: "前立腺癌に対する遺伝子治療―HSV-tk遺伝子を用いた自殺遺伝子治療―"医学のあゆみ. 192. 184-185 (1999)

Yasutomo Nasu：“前列腺癌的基因治疗 - 使用 HSV-tk 基因的自杀基因治疗”《医学史》192. 184-185 (1999)。