Study of Inhalation of Welding Fumes as a Risk Factor

吸入焊接烟雾作为危险因素的研究

• 批准号: 07671730
• 负责人: TSUSHIMA Tomoyasu
• 金额: $ 1.09万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07671730/
• 关键词: welder; welding fume; renal cell carcinoma; case control study; rat; oncogenesity; 溶接; ヒューム; 腎毒性; 発癌; 動物実験; 疫学; 鉄

Wistar male rats were tested for effects in their kidneys after inhalation of freshly formed iron oxide fume by welding. The aggregation of iron pigment was found in the lungs of rats exposed to fume in a box for 30 minutes. Macrophages in lungs took a part of the iron immediately.Twenty Wistar male rats were investigated after exposure to fume in a box for 3 hours a day, 3 days in a week, for 3 months.The rats were observed and sacrificed for a year. Most of the iron was taken in by the macrophages in the lungs and remained in the lungs for at least a year. Some were discharged from the trachea little by little and some reached mediastinal lymph nodes. Some of them was supposed to have reached the kidneys to accumulate and aggregate in renal tubular epithelial cells. Reproductive changes with swelling of nuclei and cystic changes were seen in kidneys of the rats exposed to fume after 4 months. In this research, it is possible to assume that the inhalated iron oxide may have reached kidneys and caused some nephrotoxicity. It is known that continuous injection of ferric nitrilo-triacetate (Fe-NTA) which is a kind of chilate iron causes renal cell carcinoma in rats and mice. Inhalation of iron oxide fume is possible to cause similar toxicity in humans, too.

Wistar雄性大鼠吸入焊接形成的新鲜氧化铁烟雾后，对肾脏的影响进行了测试。箱式烟雾染毒30分钟后，大鼠肺内可见铁色素聚集。Wistar雄性大鼠20只，暴露于箱内，每天3小时，每周3天，连续3个月，观察并处死1年。大部分铁被肺部的巨噬细胞吸收，并在肺部停留了至少一年。有的从气管逐渐排出，有的到达纵隔淋巴结。其中一些被认为已经到达肾脏，在肾小管上皮细胞中积聚和聚集。染尘4个月后，大鼠肾脏出现生殖改变，核肿胀，囊变。在这项研究中，可以假设吸入的氧化铁可能已经到达肾脏，并引起了一些肾毒性。已知连续注射辣椒酸铁中的氮三乙酸铁(Fe-NTA)可引起大鼠和小鼠肾细胞癌。吸入氧化铁烟雾也可能对人类造成类似的毒性。