FETAL BRAIN HYPOTHERMIA WITH ADENOSINE
FETAL BRAIN HYPOTHERMIA WITH ADENOSINE
批准号:
11671658
负责人:
SUZUKI Shunji
金额:
$2.05万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1999
资助国家:
日本
项目状态:
已结题
起止时间:
1999 至 2000
中文摘要
【目的】本研究的目的是评价窒息时腺苷对脑温度的影响。[方法]用和不用茶碱(腺苷受体阻滞剂)和丙烯茶碱(腺苷转运阻滞剂)对胎羊缺血时的脑温度进行测定。[结果]茶碱可显著降低窒息期胎儿脑相对核心温度,而丙烯茶碱无明显降低。[结论]提示腺苷对胎儿脑代谢及血流量的影响。
英文摘要
[PURPOSE] The purpose of this study is to evaluate the effect of adenosine on brain temperature during asphyxia.[METHOD] We measured brain temperature during ischemia with and without theophylline (adenosine receptor blocker) and propentofylline (adenosine transport blocker) in fetal sheep.[RESULTS] Fetal brain temperature relative core decreased significantly during asphyxia with theophylline, while it did not decrease with propentofylline.[CONCLUSION] Our results suggest the influence of adenosine against cerebral metabolism and blood flow in fetus.
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Suzuki S et al: "Changes in fetal plasma adenosine and xanthre concatenations during tetal asphyxia with material oxygen administration"Tohoku J Exp Med. 192・4(in press). (2001)
铃木 S 等人:“胎儿窒息时给予物质氧时胎儿血浆腺苷和黄酮的变化”Tohoku J Exp Med 192·4(出版中)。
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通讯作者:
Yoneyama Y et al: "Plasma adenosine levels increase in women with normal pregnancies."Am J Obstet Gynecol. 182・5. 1200-1203 (2000)
Yoneyama Y 等人:“正常妊娠的女性血浆腺苷水平增加。”Am J Obstet Gynecol 182・5 1200-1203 (2000)。
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Suzuki S et al.: "10% Malfose infusion therapy for oligohydramn'os"Ause NZ J Obstet Gynecol. 39・3. 373-375 (1999)
Suzuki S 等人:“10% Malfose 输注疗法治疗羊水过少”Ause NZ J Obstet Gynecol 39・3 (1999)。
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鈴木俊治 他: "アデノシン阻害作用を有するプロペントフィリン前投与がヒツジ臍帯圧迫モデルにおける脳温変化におよぼす影響"日産婦誌. 53・(in press). (2001)
Shunji Suzuki 等人:“具有腺苷抑制作用的丙戊茶碱预给药对绵羊脐带受压模型脑部温度变化的影响”Nissan Gynecology(2001 年出版)。
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通讯作者:
Suzuki S, et al.: "Hyperthermia prevents metabolic and cerebral blood flow responses to hypoxia in the fetal sheep."J Soc Gynecol Invest. 7. 45-50 (2000)
Suzuki S 等人:“高温可防止胎羊的代谢和脑血流对缺氧的反应。”J Soc Gynecol Invest。
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