The cerebral thermo-pooling and hypothermia treatment of perinatal brain damage.

脑热池和低温治疗围产期脑损伤。

• 批准号: 09671720
• 负责人: SUZUKI Shunji
• 金额: $ 2.18万
• 依托单位: NIPPON MEDICAL SCHOOL
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671720/
• 关键词: Fetal sheep; Brain temperature; ADENOSINE; Umbilical cord occlusion; 羊水過少; 胎子; プリン代謝産物

The purpose of this study was to compare core temperatures and brain temperatures after complete but intermittent occlusions of umbilical cord. Thermocouple probes were placed in the para-sagittal parietal cortex, ascending aorta, and jugular vein of eight near-term fetal, sheep and in the maternal descending aorta. Three days later, after an initial control period, the umbilical cord was occluded for 5 min, followed by a 30-min recovery period, and this cycle was repeated 4 times. Temperature changes, blood gases, and plasma glucose, lactate and adenosine were measured. In the first occlusion period, body core temperature increased 0.12 C over control, and then declined to baseline after cord release, and this pattern was repeated with subsequent occlusion. Plasma adenosine increased 2.4-fold during the first occlusion, but not during subsequent occlusion, despite a continuing regulator of cerebral metabolism. We conclude that brain temperature fails to increase because of diminished heat production by the brain and increases in cerebral blood flow, responses which delay complete depletion of adenosine 5Ztriphosphate stores in brain tissue.

本研究的目的是比较脐带完全但间歇性闭塞后的核心温度和大脑温度。将热电偶探头放置在8只近足月胎儿、绵羊和母体降主动脉的旁矢状顶叶皮质、升主动脉和颈静脉中。三天后，在初始控制期后，将脐带封闭5分钟，然后是30分钟的恢复期，并重复该循环4次。测量体温变化、血气、血糖、乳酸和腺苷。在第一个闭塞期，身体核心温度比对照组升高0.12 ℃，然后在脐带释放后下降到基线，并且这种模式在随后的闭塞中重复。血浆腺苷增加2.4倍，在第一次闭塞，但不是在随后的闭塞，尽管持续调节脑代谢。我们的结论是，大脑温度未能增加，因为减少热量产生的大脑和脑血流量的增加，延迟完全耗尽腺苷5Z三磷酸存储在脑组织中的反应。

项目成果

SUZUKI S.et al: "Iatrogenic monoamniotic twin gestation with progressive twin-twin transfusion syndrome" Fetal Diagn Research. 757 (in press). (1999)

SUZUKI S.等人：“医源性单羊膜双胎妊娠伴进行性双胎输血综合征”胎儿诊断研究。

Suzuki S.et al: "Maternal plasma adenosine levels in pregnancies" (Trophoblast research). 11 (in press). (1999)

Suzuki S.et al：“妊娠期母体血浆腺苷水平”（滋养层研究）。

R.Sawa: "Fetal Plasma Hypoxanthine Leve in Growth-Retarded Fetuses Be Pove Labr" Journal ol Clinical Endocrinology and Metabolism. 82・12. 4028-4031 (1997)

R.Sawa：“生长迟缓胎儿的胎儿血浆次黄嘌呤水平 Be Pove Labr”临床内分泌学和代谢杂志 82・12 4028-4031（1997）。

Kubonoya K: "Brain temperature and metabolic responses during cmbilical cord occlusion in fetal sheep" Pflugers Archiv European Journal of Physiology. 436. 667-672 (1998)

Kubonoya K：“胎羊脐带闭塞期间的脑温度和代谢反应”Pflugers Archive 欧洲生理学杂志。

Kubonoya K.: "Brain temperature and metabolic responses during umbilical cord occlusion in fetal sheep" Pflugers Archiv European Journal of Physiology. 436. 667-672 (1998)

Kubonoya K.：“胎羊脐带闭塞期间的脑温度和代谢反应”Pflugers Archive 欧洲生理学杂志。