The cerebral thermo-pooling and hypothermia treatment of perinatal brain damage.

这项研究的目的是比较脐带完全但间歇性闭塞后的核心温度和脑温度。将热电偶探头放置在8只近足月胎羊的顶叶旁矢状皮质、升主动脉和颈静脉，以及母羊的降主动脉。三天后，在最初的控制期之后，脐带闭塞5分钟，然后是30分钟的恢复期，这个循环重复4次。测量体温变化、血气、血糖、乳酸和腺苷。在第一次闭塞期间，体温比对照组升高0.12摄氏度，然后在脐带松开后下降到基线，这种模式在随后的闭塞中重复。血浆腺苷在第一次闭塞期间增加了2.4倍，但在随后的闭塞期间没有增加，尽管大脑代谢的持续调节。我们的结论是，大脑温度未能上升，是因为大脑产生的热量减少和脑血流增加，这些反应推迟了脑组织中腺苷5-三磷酸储存的完全耗尽。

The purpose of this study was to compare core temperatures and brain temperatures after complete but intermittent occlusions of umbilical cord. Thermocouple probes were placed in the para-sagittal parietal cortex, ascending aorta, and jugular vein of eight near-term fetal, sheep and in the maternal descending aorta. Three days later, after an initial control period, the umbilical cord was occluded for 5 min, followed by a 30-min recovery period, and this cycle was repeated 4 times. Temperature changes, blood gases, and plasma glucose, lactate and adenosine were measured. In the first occlusion period, body core temperature increased 0.12 C over control, and then declined to baseline after cord release, and this pattern was repeated with subsequent occlusion. Plasma adenosine increased 2.4-fold during the first occlusion, but not during subsequent occlusion, despite a continuing regulator of cerebral metabolism. We conclude that brain temperature fails to increase because of diminished heat production by the brain and increases in cerebral blood flow, responses which delay complete depletion of adenosine 5Ztriphosphate stores in brain tissue.