Experimental study about vascularized tracheo-laryngeal transfer

带血管气管喉移植的实验研究

• 批准号: 11671781
• 负责人: HOSOKAWA Ko
• 金额: $ 1.79万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671781/
• 关键词: double headed rat; head and neck transplantation; tracheo-laryngeal transplantation; 頭頸部移植; 頭頚部移植

This experiment was designed to promote the research about vascularized tracheo-laryngeal transfer in animals and brought following productions.1) A rat model of extended laryngeal transplantation combined with a tongue for clinical functional recovery was developed. In this model rats the viability of the transplanted organs was stable and survival rate of recipient was very high.2) A new rat model transplanted a head and neck without ischemic brain injury was developed. This experimental model will undoubtedly promote not only the research of vascularized tracheo-laryngeal transfer but also various fields of research about head and neck region.

本实验旨在推动血管化气管喉移植在动物体内的研究，并取得以下成果：1）建立了大鼠延长喉移植联合舌体修复临床功能的动物模型。该模型大鼠移植器官活力稳定，受体存活率高。2）建立了一种新的无缺血性脑损伤大鼠头颈部移植模型。这一实验模型的建立，不仅对带血管的气管-喉移植的研究，而且对头颈部的各个领域的研究，都有一定的促进作用。