Role of retinoic acid in craniofacial bone formation

我们分析了由软骨前体特异性Cre驱动的CYP26B1条件性基因敲除小鼠。这些小鼠正常出生，但在出生后三四周表现出严重的生长障碍。面骨较圆，形状较小，包括上下颌不平衡造成的牙合缺失。生长板中软骨细胞的减少类似于维甲酸治疗引起的并发症的表型，这被认为是临床上重要的。

We analyzed the CYP26B1 conditional knockout mice driven by cartilage precursor specific Cre. The mice were normally born, but revealed severe growth impairment at three or four weeks after birth. The facial bone was rounder and smaller in shape, including the deficiency of dental occlusion caused by the imbalance between the maxilla and the mandible. The decrease of chondrocytes in the growth plate resembled a phenotype of complications induced by retinoid therapy, which was thought to be clinically important.