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The effect of hypertension on bone decrease in hypertensive rats

高血压对高血压大鼠骨减少的影响

基本信息

批准号：
11671924
负责人：
SHIMOYAMA Kazuhiro
金额：
$ 2.5万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671924/
关键词：
hypertension salt mandible osteoporosis Dahl rat SHR rat histomorphometry 下頸骨

项目摘要

1. The effect of high salt intake on the mandibular bone in Dahl-Iwai salt-sensitive (DS) ratsTwenty-eight 11-week-old male DS rats were divided into four groups. The control groups received a normal (0.2% NaCl) diet while the experimental groups received a diet supplemented with 8.0% NaCl. The systolic blood pressure was significantly increased in the experimental groups compared to the control groups. The animals were sacrificed under ether anesthesia at the 8th week or the 22nd week of the experiment. The biochemical data in plasma and urine suggested negative calcium balance in the experimental groups compared to the control groups. The bone mineral density was significantly reduced at the 22nd week of high salt loading. The histomorphometric analysis suggested that the reduction of the mandibular bone volume had already started by the 8th week of high salt loading along with the increased bone resorption and the decreased bone formation, and that the improper bone remodeling balance became normalized by the 22nd week of high salt loading. In conclusion, these results indicate that a high salt intake causes not only severe hypertension but also a mandibular bone reduction in the DS rats.2. The effect of hypertension on bone mineral density in spontaneously hypertensive rats (SHR)The systolic-blood pressure was significantly increased in SHR compared to their normotensive genetic control Wistar Kyoto rats (WKY). There was no difference in bone mineral density of tibia and mandible between 7-week-old SHR and WKY.However, bone mineral density of tibia was significantly lower in 34-week-old SHR than in 34-week-old WKY.There was no difference in cortical bone but significant difference in cancellous bone. These results indicate that hypertension may not significantly reduce total mineral density of mandible because there is smaller amount of cancellous bone in mandible than in tibia.

1.高盐摄入对Dahl-Iwai盐敏感（DS）大鼠下颌骨的影响将28只11周龄雄性DS大鼠分为4组。对照组接受正常（0.2%NaCl）饮食，而实验组接受添加8.0%NaCl的饮食。与对照组相比，实验组的收缩压显著升高。分别于实验第8周或第22周在乙醚麻醉下处死动物。血浆和尿液中的生化数据表明，与对照组相比，实验组中的负钙平衡。高盐负荷22周时骨密度明显降低。组织形态计量学分析表明，高盐负荷沿着骨吸收增加和骨形成减少，到第8周时下颌骨体积开始减少，到第22周时，骨重建平衡趋于正常。总之，这些结果表明，高盐摄入不仅会导致严重的高血压，而且还会导致DS大鼠下颌骨减少。高血压对自发性高血压大鼠骨密度的影响自发性高血压大鼠（SHR）的收缩压显著高于其正常血压遗传对照Wistar京都大鼠（WKY）。7周龄SHR和WKY大鼠胫骨和下颌骨的骨密度差异无统计学意义，而34周龄SHR大鼠胫骨的骨密度显著低于WKY大鼠，皮质骨的骨密度差异无统计学意义，而松质骨的骨密度差异有统计学意义。结果表明，高血压可能不会显著降低下颌骨的总矿物密度，因为下颌骨中的松质骨比胫骨中的松质骨少。