Relationship between one-minute oscillation in muscular blood flow in the lower legs and one-minute wave in body fluid volume change during upright standing in humans

人体直立时小腿肌肉血流一分钟波动与体液体积变化一分钟波的关系

• 批准号: 11680020
• 负责人: INAMURA Kinsaku
• 金额: $ 1.92万
• 依托单位: Shizuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11680020/
• 关键词: one-minute wave; muscular blood flow; oxygen saturation level; hemoglobin volume; the origin; 体液量変動1分波; 組織酸素飽和度; 1分変動; 周波数分析; 周波数

To analyze how the one-minute oscillation in muscular blood flow in the lower legs relates to one-minute wave in body fluid volume change during upright standing in humans, blood flow and blood pressure in the leg, oxygen saturation level of the blood and hemoglobin volume in the tissue of the calf muscle, heart rate, stroke volume, cardiac output, peripheral blood pressure at heart level, 14 levels of body circumference, volumes of the leg, abdomen and thorax, electromyograms, foot pressure center were measured during upright standing for 40 min in 11 healthy young men. Spectral analyzes of these parameters revealed that the one-minute rhythm is found in all parameters. One-minute wave in body fluid volume change in the lower legs, which occurred in fluid pooling caused by gravity, propagated upward. Muscle pumping in the lower legs triggered by the postural sway was found to increase the power of one-minute wave. Phase analysis of one-minute oscillation revealed that the increase phase in volume of the leg, the one in the blood flow in the leg, the one in the hemoglobin volume in the tissue, elevating phase of blood pressure in the leg, and the one in oxygen saturation level of the blood were reasonably within the early phase of one-minute oscillation. The one-minute oscillation in the oxygen saturation level of the blood and the hemoglobin volume in the tissue were very clear. These results suggest that the origin of one-minute wave in body fluid volume change exists in the blood circulatory system, not in the lymph system. We conclude that the origin of one-minute wave in body fluid volume change is spontaneous constriction of peripheral blood vessels triggered by an elevation of transmural pressure when the pooling is generated.

分析小腿肌肉血流量的一分钟振荡如何与人体直立时体液体积变化的一分钟波、腿部血流量和血压、小腿肌肉组织中血液的氧饱和度水平和血红蛋白体积、心率、每搏输出量、心脏水平的外周血压、14个身体周长水平、对11名健康男性青年在直立40 min时的下肢、胸腹部容积、肌电图、足底压力中心进行了测量。对这些参数的频谱分析表明，在所有参数中均发现了一分钟节律。下肢体液体积变化的一分钟波向上传播，该波发生在重力引起的液体蓄积中。由姿势摇摆引发的小腿肌肉泵送被发现增加了一分钟波的功率。1分钟振荡的相位分析显示，腿部体积的增加相位、腿部血流量的增加相位、组织中血红蛋白体积的增加相位、腿部血压的升高相位和血液的氧饱和度水平的增加相位合理地在1分钟振荡的早期相位内。血液中的氧饱和度水平和组织中的血红蛋白体积的一分钟振荡非常清楚。提示体液容量变化的一分钟波起源于血液循环系统，而不是淋巴系统。我们的结论是一分钟波的体液体积变化的起源是自发收缩的外周血管引起的跨壁压升高时，池生成。