A research of recovery of skeletal muscle paralysis using position emission tomography

[目的]应用正电子发射断层扫描(PET)对脑卒中患者的肌肉状况进行分析。采用18F-脱氧葡萄糖(18F-FDG)正电子发射计算机断层扫描(18F-FDG)PET法测定水平行走时小鼠双腿的肌肉活动。[结果]1.首先用18F-FDGPET方法分析了正常人水平行走时的肢体肌肉活动。验证了测量肢体肌肉活动的同时效度。有趣的发现是，在水平行走时，小腿肌肉的活动量大于大腿肌肉的活动量。在所有受检肌肉中，比目鱼肌的肌肉活动最大。结论：1.臀肌中，臀小肌的肌肉活动强度大于臀大肌和臀中肌。中风偏瘫侧小腿的肌肉活动低于健康人。偏瘫侧大腿肌肉活动度与健康人相当。偏瘫侧臀小肌肌力低于健康人。非瘫痪侧内侧肌腱和胫骨后肌的肌电活动均高于健康人。PET传输模式可以检测物体的密度。我们用这种方法测量了肢体节段的体积和密度。我们证实了测量肢体节段密度的可靠性。在中风患者中观察到上臂密度降低。

[Purpose]We analyzed the muscular condition of stroke patients using positron emission tomography (PET). We measured the muscular activity of the lower extremities during level walking by 18F-fluoro-deoxyglucose (18F-FDG) PET method. We measured the volume and density of the segments of extremities by PET transmission mode.[Results]1. At first, we presented an analysis of the muscular activity of the lower extremities of healthy persons during level walking by 18F-FDG PET method. The concurrent validity of measuring the muscular activity of the lower extremity was demonstrated. The interesting findings were that,the activity of the lower leg muscles was larger than that of the thigh muscles during level walking. The muscular activity of the soleus was the largest among all the muscles examined. Among the gluteal muscles, the muscular activity of the gluteus minimus was larger than that of the gluteus maximus and gluteus medius.2. The muscular activities of the lower leg of the stroke paretic side were lower than those of healthy person. The muscular activities of the thigh of the paretic side were as large as those of healthy person. The muscular activity of the gluteus minimus of the paretic side was lower than that of healthy person. The muscular activities of the medial hamstrings and tibialis posterior of the non-paretic side were higher than those of the healthy person.3. The PET transmission mode can detect the density of object. We measured the volume and density of the segments of extremities by this method. We confirmed the reliability of measuring the density of the segments of extremities. A decrease in the density of the upper arm was observed in stroke patients.