权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Antinociceptive Effect of Central Nerve System with Linear Polarized Near-infrared Light in a Chronic Pain Model

线偏振近红外光对慢性疼痛模型中枢神经系统的镇痛作用

基本信息

批准号：
11835018
负责人：
MUNESHIGE Hiroshi
金额：
$ 2.11万
依托单位：
HIROSHIMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

项目摘要

Bennett model which is regarded as an animal model of RSD (Reflex sympathetic dystrophy) is made. Four 4-0 chromic gut sutures were tied loosely around the right sciatic nerve of the rat. The left sciatic nerve is not ligated but exposed. The hyperalgesia is evaluated with the thermal stimulation in a radiant heat test, and is done with the pressure stimulation using a von Frey hair. Radiant heat test : The rat is put on the glass plate. Then, the sole is irradiated with radiant heat from under the glass plate. Hind paw withdrawal automatically terminated the stimulus and stop the timer. Pressure test : The rat is put on the metal mesh. From under the metal mesh, the sole is stimulated with the pressure stimulation using a von Frey hair. The thickness of the filament which moves the hind paw is an index of hyperalgesia. Rats that showed hyperlgesia one week postoperatively are chosen. Single-session irradiation with linear polarized near infrared light was made near the medulla oblongata and the cerebrum sensory area, and we observe the antinociceptive effect. The hyperalgesia of the Bennett model disappears about eight week later. Rats that showed hyperlgesia one week postoperatively were chosen. We irradiates every day near the medulla oblongata for one or three weeks with linear polarized near-infrared light. We irradiates every day near the cerebrum sensory area for one or three weeks with the light. We examined whether it has recovery effect or not. Shimose makes the animal model and irradiates linear polarized near-infrared light. Muneshige makes the radiant heat test, and Shimose does the von Frey hair test. The anticipating result : Irradiation near the medulla oblongata or cerebrum sensory area with the light showed antinociceptive effect in the animal model of RSD. This shows the possibility of the effect of the light irradiation near cerebrum sensory area and medulla oblongata in the human being.

制作了反射性交感神经营养不良（RSD）的动物模型班尼特模型。将四根4-0铬肠线松散地系在大鼠的右侧坐骨神经周围。左侧坐骨神经不结扎，但暴露。在辐射热试验中用热刺激评价痛觉过敏，并使用von Frey毛发用压力刺激进行痛觉过敏。辐射热试验：将大鼠置于玻璃板上。然后，用来自玻璃板下的辐射热照射鞋底。后爪缩回自动终止刺激并停止计时器。压力试验：将大鼠置于金属网上。从金属网下面，使用von Frey毛发通过压力刺激来刺激鞋底。移动后爪的细丝的厚度是痛觉过敏的指标。选择术后一周表现出痛觉过敏的大鼠。用线偏振光近红外光照射大鼠延髓和大脑感觉区，观察其抗伤害效应。班尼特模型的痛觉过敏在8周后消失。选择术后1周出现痛觉过敏的大鼠。我们每天用线性偏振近红外光照射延髓附近，持续一到三周。我们每天用光照照射大脑感觉区附近，持续一到三周。我们研究了它是否具有恢复效果。Shimose制作动物模型，照射线偏振近红外光。宗茂做辐射热测试，下濑做冯弗雷头发测试。预期结果：光照射延髓或大脑感觉区对RSD动物模型有镇痛作用。这说明光照射在人大脑感觉区和延髓附近产生效应的可能性。