Evaluation of the effects of endocrine disruptors in synthetic compounds on several biological organisms.

评估合成化合物中内分泌干扰物对几种生物体的影响。

• 批准号: 11839026
• 负责人: KIMURA Junpei
• 金额: $ 1.54万
• 依托单位: NIHON UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11839026/
• 关键词: endocrine disruptor; smear test; plastic; nonylphenol; estrogenic activity; フタル酸エステル; ビスフェノールA; 内分泌撹乱物質; 膣前庭; 組換え酵母検出系; プラスチック製品; エストロゲン; コルチゾル

The estrogenic activity of thirty seven endocrine disruptors including byproducts from plastic gloves and food wraps, and chemicals related to nonylphenol, medical drugs and phytoestrogens, were measured by in vitro and in vivo tests. There was a good correlation between the results obtained from two in vitro tests which included a recombinant yeast test and a cultured mammary cancer cell test. Eighteen chemicals were subjected to an in vivo rat vaginal smear test. Those of the chemicals subjected, eight showed a positive correlation between results obtained from the present study and the results from Dodds's results (1938). From these correlation, the evaluation methods of plastic compounds, medical drugs and phytoestrogens in food safety and living environment were discussed.

通过体外和体内试验测定了37种内分泌干扰物的雌激素活性，包括塑料手套和食品包装的副产物，以及与壬基酚、医疗药物和植物雌激素有关的化学品。从两个体外试验（包括重组酵母试验和培养的乳腺癌细胞试验）获得的结果之间具有良好的相关性。对18种化学品进行了体内大鼠阴道涂片试验。这些化学品中，有8种在本研究中得到的结果与Dodds的结果（1938年）之间显示出正相关。从这些相关性出发，讨论了塑料化合物、医药和植物雌激素在食品安全和生活环境中的评价方法。

项目成果

J.Kimura et al.: "Immunohistochemical Localization of Inhibin and Steroidogenic Enzymes in the Ovary of Common Tree Shrew and Northern Smooth-tailed Tree Shrew."Anatomia Histologia Embryologia. 29. 267-271 (2000)

J.Kimura 等人：“普通树鼩和北方光滑尾树鼩卵巢中抑制素和类固醇生成酶的免疫组织化学定位。”解剖组织学胚胎学。