Synthesis, Biosynthesis and Mode-of-Action of Fungal Cyclopeptides

真菌环肽的合成、生物合成和作用方式

• 批准号: 530454070
• 负责人: Privatdozent Dr. Enno Klußmann
• 金额: --
• 依托单位: Max-Delbrück-Centrum für Molekulare Medizin (MDC) in der Helmholtz-Gemeinschaft
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/530454070?language=en
• 关键词: Synthesis; Biosynthesis; Mode; Action; Fungal

A small molecule and various cyclopeptides have been described to be related to intoxications from mushrooms. The chemical synthesis and the biosynthesis are unknown to date, as well as the underlying mode-of-action and the molecular target structures. Based on initial experiments, in this joint project between labs from peptide (bio)chemistry and cell biology we will investigate the origins in order to possibly find explanations for the observed physiological effects. The project comprises the chemical synthesis of the cyclopeptides, the search for the biosynthetic origin, structure-activity-relations based on the chemical synthesis of analogs, the search for the addressed receptor(s) and target structures, as well as the involvement of redistribution of the water channel aquaporin-2 between cytoplasm and membrane. The clarification of the modes-of-action could be the basis for the development of drugs.

一种小分子和各种环肽被描述为与蘑菇中毒有关。化学合成和生物合成至今未知，以及潜在的作用方式和分子靶结构。在初步实验的基础上，在这个由多肽（生物）化学和细胞生物学实验室组成的联合项目中，我们将调查其起源，以便可能地找到所观察到的生理效应的解释。该项目包括环肽的化学合成，寻找生物合成来源，基于类似物化学合成的结构-活性关系，寻找寻址受体和目标结构，以及参与细胞质和膜之间水通道水通道-2的重新分配。对作用方式的澄清可以成为开发药物的基础。