Development of a device for analyzing fine particles by exploiting acoustic radiation force and electrostatic force

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As the first step toward developing a device by which various constituents in a biological cell are analyzed, a device for concentrating nanoparticles in liquid by acoustic radiation force was assembled according previous studies, and particle distribution was observed by video microscopy. Several variables such as particle concentration, density matching of particles in liquid, particle diameter, inner wall coating of channels, and peak-to-peak amplitude of ultrasound were examined. Unfortunately, the device works in an irreproducible manner and reliable results were not obtained. Apart from this, the chemical state of the channels plays an important part in the design of such a device, because it can affect the magnitude of electroosmosis generated on the surface as well as the separation ability.Silica surface was coated with titanium dioxide in a crystalline form of anatase. The resultant surface had anodic or cathodic electroosmosis, depending on the pH and composition of the solution. Titanium dioxide surface was readily modified by a silanizing reagent so that some chromatographic interaction took place.