Study on Coevoluion of Pinworms and Their Host Primates

蛲虫与其宿主灵长类动物共同进化的研究

• 批准号: 12640684
• 负责人: HASEGAWA Hideo
• 金额: $ 1.79万
• 依托单位: OITA MEDICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12640684/
• 关键词: Primates; Pinworms; Coevolution; DNA; Speciation; Enterobius; Lemuricola; Trypanoxyuris; 系統学; 分子系統学; 染色体; 系統分類

In this research, 12 species of wild and captive primates were examined, and 12 pinworm species belonging to 3 genera were found. Among them, two were new to science, and described as Enterobius (Colobenterobius) pygatrichus (parasitic in golden monkey) and Enterobius (Colobenterobius) serratus (parasitic in proboscis monkey). Trypanoxyuris (Buckleyenterobius) atelis and Trypanoxyuris (Oxyuronema) atelophora were redescribed, and the subgenera Buckleyenterobius and Oxyuronema were reinstated. Enterobius (Enterobius) bipapillatus (parasitic in talapoin) and Enterobius (Enterobius) sp. (parasitic in Japanese monkey) were first recorded from Japan. A pair of rudimental papillae lacking connections to cuticular surface was found in the dorso-lateral areas of male tail in Trypanoxyuris spp. of the New World monkeys, and was considered to be homologous with the peculiar papillae in Lemuricola of Madagascar. Synonymy of Enterobius (Enterobius) gregoril with human pinworm E. (E.) vermicularis was ultimately proven based on sequence analysis of mtDNA CO1 and rDNA ITS2 regions, and morphological and ecological observation of developmental course. A fatal case of chimpanzee with human pinworm infection was reported, and it was demonstrated that light-pathogenic pinworm of human causes severe disease in chimpanzees. Phylogenetic reconstruction based on sequence of mtDNA CO1 and rDNA 28S regions suggested that the genus Trypanoxyuris in the New World monkeys evolved before established of Enterobius of the Old World primates and Lemuricola of lemurs.

本研究对12种野生和圈养灵长类动物进行了调查，发现蛲虫3属12种，其中2种为新记录种，分别为寄生于金丝猴的Enterobius（Colobenterobius）pygatrichus和寄生于长鼻猴的Enterobius（Colobenterobius）serratus。对锥尾虫（Trypanoxyuris（Buckleyenterobius）atelis）和锥尾虫（Trypanoxyuris（Oxyuronema）atelophora）进行了重新描述，并恢复了Buckleyenterobius和Oxyuronema亚属。双乳头蛲虫（Enterobius）bipillapiatus）和日本猴蛲虫（Enterobius）sp.（Enterobius sp.）均为日本首次发现。锥尾虫雄性尾部背外侧区有一对与表皮表面缺乏连接的残留乳头。新大陆猴的乳头状突起，被认为与马达加斯加的狐猴属特有的乳头状突起同源。蛲虫属（Enterobius）gregoril与人蛲虫E.（E.）根据线粒体DNA CO1和rDNA ITS 2区域的序列分析以及发育过程的形态学和生态学观察，最终证实了蠕虫菌的存在。本文报道了1例黑猩猩感染人类蛲虫致死病例，证明人类的轻致病性蛲虫可引起黑猩猩严重疾病。基于mtDNA CO1和rDNA 28S区序列的系统发育重建表明，新大陆猴锥虫属的进化早于旧大陆灵长类的蛲虫属和狐猴属的狐猴属。

项目成果

Ikeda, Y., Fujisaki, A., Murata, K., Hasegawa, H.: "Redescription of Pterygodermatites (Mesopectines) nycticebi (Monnig, 1920) (Nema-toda : Rictulariidae), a parasite of slow loris Nycticebus coucang (Mammalia : Primates)"Folia Parasitogica. 50(印刷中). (200

Ikeda, Y.、Fujisaki, A.、Murata, K.、Hasekawa, H.：“Pterygodermatites (Mesopectines) nycticebi (Monnig, 1920) (Nema-toda : Rictulariidae) 的重新描述，懒猴 Nycticebus coucang (哺乳动物) 的寄生虫）：灵长类动物）“Folia Parasitogica。50（正在印刷中）。（200

Murata, K., Hasegawa, H., Nakano, T., Noda, A., Yanai, T.: "Fatal infection with human pinworm, Enterobius vermicularis, in a captive chimpanzee"Journal of Medical Primatology. 31. 104-108 (2002)

Murata, K.、Hasekawa, H.、Nakano, T.、Noda, A.、Yanai, T.：“圈养黑猩猩中人类蛲虫蛲虫的致命感染”《医学灵长类动物学杂志》。

Hasegawa, H., Murata, K., Asakawa, M.: "Enterobius (Coloenterobius) pygatrichus sp. n. (Nematoda: Oxyuridae) collected from a golden monkey Pygathrix roxellana (Milne-Edwards, 1870) (Primates: Cercopithecidae: Colobinae)"Comparative Parasitology. 69(1). 6

长谷川 H.、村田 K.、浅川 M.：“从金丝猴 Pygathrix roxellana 中收集的 Enterobius (Coloenterobius) pygatrichus sp. n.（线虫纲：Oxyuridae）（Milne-Edwards，1870）（灵长类动物：Cercopithecidae：Colobinae）

Hasegawa, H., Murata, K.Asakawa, M.: "Enterobius (Colobenterobius) pygatrichus sp. n. (Nematoda : Oxyuridae) collected from a golden monkey Pygathrix roxellana (Milne-Edwards, 1870) (Primates : Cercopithecidae:"Comparative Parasitology. 69(1). 62-65 (2002

Hasekawa, H., Murata, K.Asakawa, M.：“Enterobius (Colobenterobius) pygatrichus sp. n.（线虫纲：Oxyuridae）从金丝猴 Pygathrix roxellana 中采集（Milne-Edwards，1870）（灵长类动物：Cercopithecidae：”比较

Ikeda, Y., Fujisaki, A., Murata, K., Hasegawa, H.: "Redescription of Pterygodermatites (Mesopectines) nycticebi (Monnig, 1920) (Nematoda : Rictulariidae), a parasite of slow lorid Nycticebus coucang (Mammalia : Primates)"Folia Parasitologica. 50. 115-120

Ikeda, Y.、Fujisaki, A.、Murata, K.、Hasekawa, H.：“Pterygodermatites (Mesopectines) nycticebi (Monnig, 1920)（线虫纲：Rictulariidae）的重新描述，一种慢蜥蜴 Nycticebus coucang（哺乳动物：灵长类）的寄生虫