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Formation and Retention of Novel Framework of Metal Complexes through multi-elemental sites

通过多元素位点形成和保留金属络合物新型框架

基本信息

批准号：
12650678
负责人：
NOMURA Ryoki
金额：
$ 2.3万
依托单位：
Osaka Institute of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

项目摘要

It is found that some novel complex assembly can be synthesized by an introduction of hydrogen bonding sites such as OH groups on the outer sphere of transition metal dithiocarbarnate complexes. For example, we prepared novel dithiocarbarnate complexes of transition metals having OH groups at the positions leading to C2 symmetry and some Ni and Cu complexes can form novel complex assembly with micro-channel structure. These micro-channel structures should lead to developing a new receptor. On the other hand, Zn analogues did not form such complex assemblies but formed dimmer with bridging dithiocarbamate ligands. Omega OH groups of the Zn complexes surrounding (Zn-S) 2 core maintained C2 symmetry against the core. Consequently, an approach of some guest molecules may stimulate OH groups on the outer sphere to change the conformation around the central metals. This finding perhaps leads to new biosensors.Next we investigated the scope and limitations of such type of complex assembly for developing new bio-sensing devices. For example, preparation of some zinc complexes with N-protected oligo-peptide chains as ligands was investigated. Further, spectral investigations on the intermolecular and/or inter-ligand interactions of those zinc complexes were attempted. Thus, it is found that these oligo-peptide chains can form some inter ligand interactions although they were locked to the central metals. Additionally, it can be said an approach of some marker molecules to the ligand should affect the conformational change around the central metals. Such conformational changes were considered to actuate the signals generated by the approach of the marker.

研究发现，在过渡金属二硫代碳酸盐配合物的外球上引入氢键位点，如OH基团，可以合成一些新的配合物组合。例如，我们制备了新型的过渡金属二硫代碳酸盐配合物，在C2对称的位置具有OH基团，一些Ni和Cu配合物可以形成具有微通道结构的新型配合物组装体。这些微通道结构将导致一种新的受体的开发。另一方面，锌类似物不形成这种复杂的组装体，而是与桥接二硫代氨基甲酸酯配体形成二聚体。围绕（Zn- s） 2核心的锌配合物的ω - OH基团与核心保持C2对称。因此，一些客体分子的接近可能会刺激外球上的OH基团改变中心金属周围的构象。这一发现可能会带来新的生物传感器。接下来，我们研究了这种类型的复杂组装开发新的生物传感装置的范围和局限性。例如，研究了以n保护寡肽链为配体的锌配合物的制备。此外，对这些锌配合物的分子间和/或配体间相互作用进行了光谱研究。因此，我们发现这些寡肽链可以形成一些配体间的相互作用，尽管它们被锁定在中心金属上。此外，可以说一些标记分子接近配体应该影响中心金属周围的构象变化。这种构象变化被认为是由标记物接近所产生的信号驱动的。