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The Effect of Physical Exercise for Hemiparetic Stroke Patients Assessed by EEG and Motor Evoked Potential

脑电图和运动诱发电位评估体育锻炼对脑卒中偏瘫患者的影响

基本信息

批准号：
12832009
负责人：
SEKI Kazunori
金额：
$ 1.66万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12832009/
关键词：
EEG Motor Evoked Potential Hemiparesis Stroke 脳卒中片麻痺

项目摘要

The purpose of this study is to investigate the effect of physical exercise like gait training to the central nervous system of hemiparetic stroke patients through examining EEG, motor evoked potential (MEP) induced by transcortical magnetic stimulation and body balance. The subjects were 9 hemiparetic stroke patients who admitted to Tohoku University Hospital for rehabilitation within 3 months after a stroke onset. EEG was examined before, during and after walking in 10 m distance with maximum effort in each subject. MEP and body balance were measured before and 1 month after physical therapy. The value of relative power (ratio of the power in target band to total power) was calculated to analyze EEG in each hemisphere. During walking, there was significant decrease of the values of relative power in alpha band in the both hemispheres especially in the front-central area. Alpha attenuation in the front-central area of the both hemispheres during walking suggested general augmentation of the cortical activity associated with voluntary movement like the inhibition of mu rhythm. The beta activity increased in the injured hemisphere during walking and in the non-injured hemisphere after walking. These results suggested that walking had the effect of activating the brain function even after walk in the stroke patients. MEP did not change between before and after physical therapy. It showed physical exercise had no specific effect to activate the motor cortex. Center of pressure as a parameter of body balance was improved 1 month after physical therapy but it was also improved by one shot application of the electrical stimulation to the paretic lower limb. Therefore the effect of physical exercise for the central nervous system is similar to it of physical agent like electrical stimulation and it is supposed that such effect is general augmentation of the brain function.

本研究旨在通过对脑卒中偏瘫患者的脑电图（EEG）、经皮层磁刺激诱发的运动诱发电位（MEP）和身体平衡的检测，探讨步态训练等体育锻炼对脑卒中偏瘫患者中枢神经系统的影响。研究对象为9名中风偏瘫患者，他们在中风发作后3个月内入住东北大学医院进行康复治疗。EEG检查之前，期间和之后，在10米的距离，在每个主题的最大努力步行。运动前和运动后1个月分别进行MEP和身体平衡测试。计算相对功率值（目标频带功率与总功率的比值），分析各半球的EEG。行走过程中，两半球α波相对功率值均显著下降，以前中央区下降最为明显。在行走过程中，两个半球的前部中央区域的α衰减表明与自主运动相关的皮质活动的普遍增强，如μ节律的抑制。在行走过程中受伤的半球和行走后未受伤的半球中的β活性增加。这些结果表明，步行对脑卒中患者即使在步行后也具有激活脑功能的作用。MEP在物理治疗前后没有变化。这表明体育锻炼对激活运动皮层没有特异性作用。作为身体平衡参数的压力中心在物理治疗后1个月得到改善，但对麻痹下肢进行一次性电刺激也得到改善。因此，体育锻炼对中枢神经系统的影响与电刺激等物理因素的影响相似，并且这种影响被认为是大脑功能的普遍增强。