The elucidation of the mechanisms of cardiovascular hypertrophy and hyperplasia and the establishment of angiogenesis by therapeutic electrical stimulation

我们评估了61名日本肺气肿住院患者的运动表现、心理状态、日常生活活动（ADL）和健康相关生活质量（HRQL）水平，采用疾病影响谱（SIP）和线性模拟量表（QOL量表）进行评估。大约一半的人有严重的焦虑和抑郁倾向。根据美国胸科学会（ATS）的定义，在COPD肺功能严重程度的II期，ADL的残疾是明显的。III期患者需要帮助维持他们的ADL。在SIP阶段，ATS阶段越高，运动表现和ADL受到的损害越大。而心理状态、HRQL与ATS分期无显著相关。这些结果表明，肺功能不是日本肺气肿患者心理状态和HRQL的简单决定因素。我们评估了肺气肿肺减容手术（LVRS）对HRQL的长期影响，通过对接受肺康复和LVRS （A组）的严重肺气肿患者LVRS前后的疾病影响特征（SIP），以及肺功能、运动表现和ADL的测量来评估。重度肺气肿患者行肺康复但未行LVRS作为对照组（B组）。lvrs后3个月肺功能、运动表现和ADL均有明显改善，随访12个月均维持正常。A组在lvrs后3个月SIP-overall评分和SIP-physical评分均显著提高，并在随访6个月和12个月时保持不变。12个月时sip -社会心理评分显著提高。B组患者在肺康复后6个月和12个月的SIP评分较A组明显降低。这些结果表明，LVRS不仅可以改善肺功能、运动表现和ADL，还可以改善HRQL，并且这些改善在术后至少维持12个月。

We evaluated exercise performance, psychological state, activities of daily living (ADL) and health-related quality of life (HRQL) levels, assessed using the sickness impact profile (SIP) and the linear analogue scale (QOL Scale) in 61 Japanese in-patients with emphysema. About half of them had severe anxiety and depression tendencies. Disabilities of ADL were apparent in stage II of COPD lung function severity as defined by the American Thoracic Society (ATS). Patients who were stage III required help maintaining their ADL. In the SIP, the higher the ATS stages, the more exercise performance and ADL impaired. However, psychological state and HRQL are not significantly correlated with ATS stages. These results indicate that lung function is not a simple determinant of psychological state and HRQL in Japanese patients with emphysema.We evaluated the long-term impact of lung volume reduction surgery (LVRS) for emphysema on HRQL assessed by the sickness impact profile (SIP) before and after LVRS in patients with severe emphysema who underwent pulmonary rehabilitation and LVRS (group A), along with measurements of lung function, exercise performance, and ADL. The patients with severe emphysema who underwent pulmonary rehabilitation but did not undergo LVRS served as a control group (group B).Lung function, exercise performance and ADL were improved significantly at 3 months post-LVRS and even maintained at 12 months follow-up. In group A, both SIP-overall score and SIP-physical score were improved significantly at 3 months post-LVRS and maintained at 6 and 12 months follow-ups. SIP-psychosocial score was improved significantly at 12 months. In group B, SIP scores were significantly impaired compared with group A at 6 and 12 months after pulmonary rehabilitation.These results suggest that LVRS improves not only lung function, exercise performance, and ADL, but also HRQL and these improvements are maintained for at least 12 months after the operation.