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The elucidation of the mechanisms of cardiovascular hypertrophy and hyperplasia and the establishment of angiogenesis by therapeutic electrical stimulation

阐明心血管肥大和增生的机制以及通过治疗性电刺激建立血管生成

基本信息

批准号：
12832008
负责人：
YOSHIDA Kazunori
金额：
$ 2.43万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

项目摘要

We evaluated exercise performance, psychological state, activities of daily living (ADL) and health-related quality of life (HRQL) levels, assessed using the sickness impact profile (SIP) and the linear analogue scale (QOL Scale) in 61 Japanese in-patients with emphysema. About half of them had severe anxiety and depression tendencies. Disabilities of ADL were apparent in stage II of COPD lung function severity as defined by the American Thoracic Society (ATS). Patients who were stage III required help maintaining their ADL. In the SIP, the higher the ATS stages, the more exercise performance and ADL impaired. However, psychological state and HRQL are not significantly correlated with ATS stages. These results indicate that lung function is not a simple determinant of psychological state and HRQL in Japanese patients with emphysema.We evaluated the long-term impact of lung volume reduction surgery (LVRS) for emphysema on HRQL assessed by the sickness impact profile (SIP) before and after LVRS in patients with severe emphysema who underwent pulmonary rehabilitation and LVRS (group A), along with measurements of lung function, exercise performance, and ADL. The patients with severe emphysema who underwent pulmonary rehabilitation but did not undergo LVRS served as a control group (group B).Lung function, exercise performance and ADL were improved significantly at 3 months post-LVRS and even maintained at 12 months follow-up. In group A, both SIP-overall score and SIP-physical score were improved significantly at 3 months post-LVRS and maintained at 6 and 12 months follow-ups. SIP-psychosocial score was improved significantly at 12 months. In group B, SIP scores were significantly impaired compared with group A at 6 and 12 months after pulmonary rehabilitation.These results suggest that LVRS improves not only lung function, exercise performance, and ADL, but also HRQL and these improvements are maintained for at least 12 months after the operation.

我们评估了61例日本肺气肿住院患者的运动表现、心理状态、日常生活活动（ADL）和健康相关生活质量（HRQL）水平，使用疾病影响特征（SIP）和线性模拟量表（QOL量表）进行评估。大约一半的人有严重的焦虑和抑郁倾向。根据美国胸科学会（ATS）的定义，在COPD肺功能严重程度的II期中，ADL障碍明显。III期患者需要帮助维持ADL。SIP患者ATS分级越高，运动能力和ADL受损越严重。然而，心理状态和HRQL与ATS分期无显著相关性。这些结果表明，肺功能不是日本肺气肿患者心理状态和HRQL的简单决定因素。我们评估了肺减容手术（LVRS）对重度肺气肿患者HRQL的长期影响，该患者接受了肺康复和LVRS（A组），沿着肺功能测量，运动表现和ADL。对照组（B组）为重度肺气肿患者，行肺功能康复治疗，但未行LVRS，术后3个月肺功能、运动能力和ADL均明显改善，随访12个月仍能维持。在A组中，LVRS后3个月SIP总分和SIP体格评分均显著改善，并在随访6个月和12个月时保持不变。12个月时SIP-心理社会评分显著改善。B组患者术后6个月和12个月的SIP评分较A组明显降低，提示LVRS不仅改善了肺功能、运动能力和ADL，而且改善了HRQL，这些改善至少在术后12个月保持。