Does streptococcal ADP ribosyl cyclase/cADPR hydrolase evokeIgdassswitch?

链球菌 ADP 核糖基环化酶/cADPR 水解酶是否会引起 Igdass 开关？

• 批准号: 12670251
• 负责人: KARASAWA Tadahiro
• 金额: $ 2.18万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670251/
• 关键词: streptococcus pyogenes; cyclic ADP-ribose; NAD; レンサ球菌; サイクリックADPリボース

1. Distinct evidence of Ig class switch was not obtained when hybridoma cells were incubated with purified streptococcal ADP ribosyl cyclase/cADPR hydrolase.2. The microbiologic status of streptococcal pharyngitis in pediatric outpatients was investigated. Children with clinical diagnosis of acute pharyngitis were enrolled. Of 360 specimens examined, 96 (26.7%) were beta hemplytic streptococci (BHS)-positive. The isolates were homogeneous for Lancefield's group and T antigen. Although group A was predominant (90 isolates, 93.8%), groups B (two isolates, 2.1%), C (one isolate, 1.0%), and G (three isolates, 3.1%) were also detected. It should be noticed that non-group A streptococci can not be detected with the currently used rapid antigen-detection tests. The results of T-serotyping suggest that human migration during summer vacation may provide an opportunity for streptococci to colonize in new hosts.

1.当杂交瘤细胞与纯化的链球菌ADP核糖基环化酶/cADPR水解酶共同孵育时，没有获得明显的IG类别转换的证据.对门诊儿童链球菌性咽炎的微生物学状况进行了调查。入选临床诊断为急性咽炎的儿童。在360份检查标本中，96份（26.7%）为β-血友病链球菌（BHS）阳性。分离株的兰斯菲尔德群和T抗原均为同种型。虽然A群占优势（90株分离株，93.8%），但也检测到B群（2株分离株，2.1%）、C群（1株分离株，1.0%）和G群（3株分离株，3.1%）。值得注意的是，目前使用的抗原快速检测试验不能检测非A组链球菌。T-血清分型的结果表明，在暑假期间的人类迁移可能提供了一个机会，链球菌定植在新的主机。

项目成果

Karasawa, T.: "Epidemiological survey of β-rhemplytic streptococci isolated irom acute pharyngitis irta priyate pedialric practice"Jpn. J. Infect. Dis.. 54(2). 76-77 (2001)

Karasawa，T.：“急性咽炎儿科实践中分离出的 β-溶血性链球菌的流行病学调查”Jpn. Infect. 76-77 (2001)。

Karasawa, T.: "Isolation of β-hemolytic streptococci (BHS) from acute pharyngitis in a private pediatric practice"Proceeding of 10^<th> conference of Japanese Lancefield Society. (発売予定). (2002)

Karasawa, T.：“在私人儿科实践中从急性咽炎中分离β-溶血性链球菌（BHS）”日本兰斯菲尔德学会第 10 届会议记录（即将发布）。

唐澤忠宏: "A群溶連菌"感染と抗菌薬. 4(4). 306-307 (2001)

Tadahiro Karasawa：“A 族链球菌”感染和抗菌药物 4(4) 306-307 (2001)。

Karasawa, T.: "Epidemiological survey of β-hemolytic streptococci isolated from acute pharyngitis in a private pediatric practice"Jpn. J. Infect. Dis.. 54(2). 76-77 (2001)

Karasawa, T.：“私人儿科诊所中分离出的β-溶血性链球菌的流行病学调查”Jpn. Infect.. 76-77 (2001)。

Karasawa, T.: "Isolation of β-hemolytic streptococci (BHS) from acute pharyngitis in a private pediatric practice"Proceeding of 10^<th> conference of Japanese Lancefield Society. (発表予定). (2002)

Karasawa, T.：“在私人儿科实践中从急性咽炎中分离β-溶血性链球菌（BHS）”日本兰斯菲尔德学会第 10 届会议记录（即将发表）。