A NESTED CASE-CONTROL STUDY ON THE INTERACTION BETWEEN HCV AND HTLV-I IN THE DEVELOPMENT OF LIVER CANCER

HCV 与 HTLV-I 在肝癌发生过程中相互作用的巢式病例对照研究

基本信息

批准号：
12670363
负责人：
ARISAWA Kokichi
金额：
$ 1.6万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670363/
关键词：
HTLV-I HCV Liver cancer Biliary tract cancer Interaction Nested Case-control study Ecologic study Adult T-cell leukemia lymphoma 肝細胞がん罹患率

项目摘要

(1) Geographic Distribution of the Incidence of Adult T-cell Leukemia/lymphoma and Other Malignancies in Nagasaki Prefecture, JapanBackground: It remains unclear whether human T-cell lymphotropic virus type-I (HTLV-I) infection is associated with an increased risk of malignancies other than adult T-cell leukemia/lymphoma.Methods: The authors investigated the geographic distribution of the incidence of adult T-cell leukemia/lymphoma and other malignancies in Nagasaki Prefecture, Japan, where HTLV-I is endemic. The world age-standardized incidence rates of adult T-cell leukemia/lymphoma and five cancers of other sites were calculated in 15 areas, using the data from the Nagasaki Prefectural Cancer Registry (1985-1997).Results and Conclusions: The incidence of adult T-cell leukemia/lymphoma was found to be positively correlated with that of biliary tract cancer in men (person-years-weighted r = 0.49, P = 0.06) and liver cancer in women (r = 0.56, P = 0.03), but not with cancer of the stom … More ach, lung or cervix uteri. The results may not support the hypothesis that HTLV-I infection is strongly associated with an increased risk of cancer of the stomach, lung or cervix uteri. The significant correlation between adult T-cell leukemia/lymphoma and liver cancer may be explained by the simple coincidence of the distribution of HTLV-I and hepatitis C/B viruses, and/or the effects of HTLV-I infection to promote the progression from hepatitis C/B viral infections to chronic hepatitis, liver cirrhosis and liver cancer. The association between HTLV-I infection and cancer of the biliary tract is of concern and should be evaluated on an individual basis in future epidemiologic studies.(2) A nested case-control study of risk factors for adult T-cell leukemia/lymphoma among human T-cell lymphotropic virus type-I carriers in JapanObjectives: The purpose of this study was to investigate the serological risk factors for development of adult T-cell leukemia/lymphoma (ATL) among human T-cell lymphotropic virus type-I (HTLV-I) carriers.Methods: A nested case-control study was performed. The source population comprised 23,922 subjects who had either visited the outpatient clinic or who had received annual health check-ups at the K Hospital, Nagasaki, Japan, at least once during 1985-1996 (HTLV-I seroprevalence = 16. 1 %). Markers of HTLV-I infection were examined in stored sera from 29 incident cases of ATL diagnosed during 1985-1997, and 156 controls matched for sex, birth year, date of sample collection and HTLV-I seropositivity.Results: In exact conditional logistic regression analysis, high soluble interleukin-2 receptorlevels (>=500 U/ml) and high HTLV-I antibody titers (>=1,024) were significantly associated with an increased risk of developing ATL (Odds ratio was 26.3, 95 % confidence interval [CI] 6.0241 and 3.5, 95 % CI 1.4-9.1, respectively). The results remained essentially unchanged when the subjects were restricted to those whose histories were followed for 2 years or longer.Conclusions: These findings indicate that high soluble interleukin-2 receptor levels and high HTLV-I antibody liters are strong predictors of ATL among carriers of HTLV-I. Less

（1）日本背景的长崎县的成年T细胞白血病/淋巴瘤和其他恶性肿瘤的发生率的地理分布：尚不清楚人类T细胞淋巴病毒I型（HTLV-I）是否与成人T-Cell Leukemia extraighte rymphoma的其他风险相关。日本长崎县的成年T细胞白血病/淋巴瘤和其他恶性肿瘤的发病率，HTLV-I为htlv-i是内在的。 The world age-standardized incident rates of adult T-cell leukemia/lymphoma and five cancers of other sites were calculated in 15 areas, using the data from the Nagasaki Prefectural Cancer Registry (1985-1997).Results and Conclusions: The incident of adult T-cell leukemia/lymphoma was found to be positively correlated with that of biliary tract cancer in men (person-years-weighted r = 0.49，p = 0.06）和女性的肝癌（r = 0.56，p = 0.03），但不能与Stom的癌症相比……更多ACH，肺或子宫颈子宫。结果可能不支持HTLV-1感染与胃，肺或子宫颈子宫颈癌的风险增加密切相关的假设。成人T细胞白血病/淋巴瘤与肝癌之间的显着相关性可以通过简单的HTLV-I分布和丙型肝炎C/B病毒的简单重合，以及/或HTLV-I感染的影响，以促进肝炎病毒从肝炎中促进肝炎对肝炎的肝炎进展。 HTLV-1感染与胆道的癌症之间的关联是令人关注的，应在未来的流行病学研究中以个人为基础进行评估。（2）对成人T-Cell白血病/淋巴瘤的风险因素的嵌套病例对照研究研究人类T-Cell淋巴管型在日本型型中的潮流危险中，这是对日本研究的疾病的发展：日本研究的目的：日本研究的目的：日本研究的目的：日本研究的目的：这项研究的目的：日本研究的目的：这项研究的目的是该研究的危险。人类T细胞淋巴病毒I型（HTLV-I）携带者中的白血病/淋巴瘤（ATL）进行。方法：嵌套的病例对照研究。来源人群包括访问门诊诊所或在1985 - 1996年至少在日本长崎K医院接受年度健康检查的23,922名受试者（htlv-i Seraoprenence =16。1％）。在1985年至1997年的29例ATL诊断事件中的储存的血清中检查了HTLV-1感染的标志物，性别，出生年份，样本收集日期和HTLV-I血清的156个对照组合。回顾性：精确的逻辑回归分析，确切的条件固体固体固体式固体固体量化器（> 500 u/ml）及其较高的HIMLIB（> = 500 u/ml）。（> = 1,024）与发展ATL的风险增加显着相关（比值比分别为26.3，95％置信区间[CI] 6.0241和3.5，95％CI 1.4-9.1）。当受试者仅限于经过2年或更长时间的历史的受试者时，结果基本上保持不变。结论：这些发现表明，HTLV-I载体中ATL的高固体白介素-2受体水平和高HTLV-I抗体效果是强有力的预测指标。较少的