An investigation on pathophsiology and treatment of atopic diseases

特应性疾病的病理生理学和治疗研究

• 批准号: 12670416
• 负责人: OKUDAIRA Hirokazu
• 金额: $ 2.18万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670416/
• 关键词: Bronchial asthma; atopic dermatitis; viral and bacterial infection; eosinophillic inflammation; Th2 cytokine; IL-5; Epstein-Barr virus; ウィルスおよび細菌感染; Epstein-Barrウィルス; アレルギー; T細胞; 遺伝子転写; NF-IL5; 好酸球; ハイブリドーマ

In the present study we have shown that enhanced antibody responses against Epstein-Barr virus (EB V) in early childhood (0-10 years of age) was closely correlated with the development of atopic diseases such as bronchial asthma or atopic dermatitis. The findings obtained in the present investigation supported the idea that environmental factors are more important than hereditary factors as we have suggested. The decreases of the quantity of antibodies against EBV maternally transmitted in the so-called developed countries may result in the enhanced biological response against EBV and increased development of atopic diseases.

在本研究中，我们已经表明，在儿童早期（0-10岁），对爱泼斯坦 - 巴尔病毒（EB V）的抗体反应增强与特应性疾病（例如支气管哮喘或特应性皮炎）的发展密切相关。在本研究中获得的发现支持了这样一个观点，即环境因素比我们建议的正文因素更重要。在所谓的发达国家中对EBV产生传播的抗体数量的减少可能会导致对EBV的生物学反应增强，并增加了特应性疾病的发展。

项目成果

Okudaira H, et al.: "Biologically active recombinant forms of a major house dust mite group 1 allergen Der f1 with full activities of both cysteine protease and IgE binding"Clin Exp Allergy. 31(1). 116-124 (2001)

Okudaira H 等人：“主要屋尘螨第 1 组过敏原 Der f1 的生物活性重组形式，具有半胱氨酸蛋白酶和 IgE 结合的全部活性”Clin Exp Allergy。

Okudaira,H. et al.: "Understanding and coping with atopic diseases."Allergy Clin Immunol Int. (in press). (2000)

奥平，H.

Okudaira,H. et al.: "Pathogenesis of allergic diseases : interactions between pollutants and pollens really important?"Allerg Immunol. 32(2). 94-96 (2000)

奥平，H.

Okudair,H. et al.: "Transcriptional regulation of IL-5 gene by nontransformed human T cells through the proximal proximal promoter element."Intern Med. 39(8). 618-25 (2000)

奥库代尔，H.

Okudaira H, et al.: "Biologically active recombinant forms of a major house dust mite group 1 allergen Der f 1 with full activities of both cysteine protease and IgE binding"Clin Exp Allergy.. 31(1). 116-124 (2001)

Okudaira H 等人：“主要屋尘螨第 1 组过敏原 Der f 1 的生物活性重组形式，具有半胱氨酸蛋白酶和 IgE 结合的全部活性”Clin Exp Allergy.. 31(1)。