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Analysis of modulation of expression of cellular prion-related protein by skin immune sells

Analysis of modulation of expression of cellular prion-related protein by skin immune sells
皮肤免疫信号对细胞朊病毒相关蛋白表达的调节分析
批准号:
12670809
负责人:
NAKAMURA Koichiro
金额:
$1.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2000
资助国家:
日本
项目状态:
已结题
起止时间:
2000 至 2001

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中文摘要
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英文摘要
The modulation of expressions of cellular prion-related protein was examined in skine immune cells such as ep demal Langerhans cells (LC) and kesahisocyles (KC). The presence of prp^c on LC,DC in the skin, and KC was demonstrated in immunohis to chenical stauning, immunoblot and FACS, PrPc knock out mice showed negative PrPC expression on these cells and γδ^+TCR dendritic epidemal T cells (DETC ).In uitro examination revealed that TNFα, IL-1β uprequlated R-P^c expresnin on LC, and GM-CSF down requlated this expression. These data suggist that LC and KC may be the targets for peripheral in fection with prion proteins.
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Tada Y, et al: "Granulocyte/macrophage colony stimulating factor inhibits IL-12 production of mouse Langerhans cells."J Immunol. 164. 5113-5119 (2000)
Tada Y 等人:“粒细胞/巨噬细胞集落刺激因子抑制小鼠朗格汉斯细胞的 IL-12 产生。”J 免疫学杂志。
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Tada Y, et al.: "Transforming growth factor-β upregulates CD40-engaged IL-12 Production of mouse Langerhans cells"Eur J Immunol.. 31. 294-300 (2001)
Tada Y 等人:“转化生长因子-β 上调 CD40 接合的小鼠朗格汉斯细胞的 IL-12 产生”Eur J Nutrition.. 31. 294-300 (2001)
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Wakugawa, Nakamura K, et al.: "CC chemokine receptor 4 expression on peripheral blood CD4+T cells reflects disease activity of atopic dermatitis"Journal of Investigative Dermatology. 117. 188-196 (2001)
Wakukawa、Nakamura K 等人:“外周血 CD4 T 细胞上的 CC 趋化因子受体 4 表达反映了特应性皮炎的疾病活动性”《皮肤病学研究杂志》。
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Watanabe T, Nakamura K, et al.: "Antibodies to mollus cam contagiosum virus in the general population and susceptible patients"Archives of Dermatology. 136. 1518-1522 (2001)
Watanabe T、Nakamura K 等人:“普通人群和易感患者中传染性软体动物病毒的抗体”皮肤病学档案。
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23
    Analysis of prion protein expression on human cutaneous dendritic cells
    Analysis of cutaneous Langerhans cells and dendritic cells.
    • 批准号:
      08670950
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.22万
    • 财政年份:
      1996
    • 负责人:
      NAKAMURA Koichiro
    • 依托单位:
    海外基金