Association of GRO-α in the genesis of malignant melanoma

恶性黑色素瘤是一种预后较差的皮肤肿瘤，经常复发和转移。因此，了解其发生发展机制具有重要意义。与其他色素性皮肤病和肿瘤相比，我们研究了几个可能在黑素生成和肿瘤发生中起作用的因素的关联。在老年性雀斑的情况下，角质形成细胞衍生的内皮素1被证明与黑素生成有关。皮肤纤维瘤上皮的色素沉着是由于干细胞因子和肝细胞生长因子上调而激活黑素细胞所致。在基底细胞癌中，干细胞因子被怀疑与其色素沉着有关。在几种细胞系中研究了Gro-α在恶性黑色素瘤发生中的作用，发现大多数细胞系中都有表达。这一发现可能提示Gro-α在黑色素瘤细胞的转化和进展中起重要作用。

Malignant melanoma is a poor prognostic skin tumor, which recurs and metastasizes frequently. Thus, it is important to know the mechanism of its genesis and progression. We studied the association of several factors which might have some roles in melanogenesis and genesis of that tumor, in comparison with other pigmentary skin disorder and tumors.In case of senile lentigo, keratinocyte derived Endothelin 1 is shown to be associated to melanogenesis. The pigmentation of overlying epidermis of dermatofibroma is brought by activation of melanocyte through up-regulation of Stem cell factor and Hepatocyte growth factor. In basal cell carcinoma, Stem cell factor was suspected to be associated with its hyperpigmentation. The role of GRO-α in the genesis of malignant melanoma was studied in several cell lines, and we found the expression of mRNA in most cell lines by RT-PCR. This findings may suggest the important role of GRO-α in transformation and progression of melanoma cells.