Association of GRO-α in the genesis of malignant melanoma

GRO-α与恶性黑色素瘤发生的关系

• 批准号: 12670841
• 负责人: KAWASHIMA Makoto
• 金额: $ 2.05万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670841/
• 关键词: malignant melanoma; growth related oncogene α; endothelin; stem cell factor; hepatocyte growth factor; RT-PCR; Growth regulated oncogene α; GROα; 腫瘍

Malignant melanoma is a poor prognostic skin tumor, which recurs and metastasizes frequently. Thus, it is important to know the mechanism of its genesis and progression. We studied the association of several factors which might have some roles in melanogenesis and genesis of that tumor, in comparison with other pigmentary skin disorder and tumors.In case of senile lentigo, keratinocyte derived Endothelin 1 is shown to be associated to melanogenesis. The pigmentation of overlying epidermis of dermatofibroma is brought by activation of melanocyte through up-regulation of Stem cell factor and Hepatocyte growth factor. In basal cell carcinoma, Stem cell factor was suspected to be associated with its hyperpigmentation. The role of GRO-α in the genesis of malignant melanoma was studied in several cell lines, and we found the expression of mRNA in most cell lines by RT-PCR. This findings may suggest the important role of GRO-α in transformation and progression of melanoma cells.

恶性黑色素瘤是一种预后不良的皮肤肿瘤，经常复发和转移。因此，了解其发生和发展的机制非常重要。我们研究了几个可能在黑素生成和肿瘤发生中起一定作用的因素的关联，并与其他色素沉着皮肤疾病和肿瘤进行了比较。皮肤纤维瘤的上覆表皮的色素沉着是通过干细胞因子和肝细胞生长因子的上调激活黑素细胞而引起的。在基底细胞癌中，干细胞因子被怀疑与其色素沉着有关。本研究在几种恶性黑色素瘤细胞系中研究了GRO-α在恶性黑色素瘤发生中的作用，并通过RT-PCR发现GRO-α在大多数细胞系中有mRNA的表达。提示GRO-α在黑色素瘤细胞的转化和发展中起重要作用。

项目成果

Satsuki Kadono, Izumi Manaka, Makoto Kawashima, Takashi Kobayashi, Genji Imokawa: "The role of the epidermal endothelin cascade in the hyper pigmentation mechanism of lentigo senilis"J Invest Dermatol. 116. 571-577 (2001)

Satsuki Kadono、Izumi Manaka、Makoto Kawashima、Takashi Kobayashi、Genji Imokawa：“表皮内皮素级联在老年雀斑色素过度沉着机制中的作用”J Invest Dermatol。

Satsuki Kadono, Izumi Manaka, Makoto Kawashima, Takashi Kobayashi, | and Genji Imokawa: "The role of the epidermal endothelin cascade> in the hyperpigmentation mechanism of lentigo senilis"J. Invest. T. l-WT (2001)

角野五月、真中泉、川岛诚、小林隆、|

Etsuko Shishido, Satsuki Kadono, Izumi Manaka, Makoto Kawashima, and Genji Imokawa: "The mechanism of epidermal hyperpigmeritation in dermatofibroma is associated with stem cell factor and hepatpcyte growth factor expression"T invest. 7. 27-633 (2001)

Etsuko Shishido、Satsuki Kadono、Izumi Manaka、Makoto Kawashima 和 Genji Imokawa：“皮肤纤维瘤中表皮过度色素化的机制与干细胞因子和肝细胞生长因子的表达有关”Tinvest。

Etsuko Shishido, Satsuki Kadono, Izumi Manaka, Makoto Kawashima, Genji Imokawa: "The mechanism of epidermal hyperpigmentation in dematofibroma is associated with stem cell factor and hepatpcyte growth factor expression"J invest Dermatol. 117. 627-633 (200

Etsuko Shishido、Satsuki Kadono、Izumi Manaka、Makoto Kawashima、Genji Imokawa：“去肿纤维瘤中表皮色素沉着过度的机制与干细胞因子和肝细胞生长因子的表达有关”Jinvest Dermatol。

S.Kadono, I.Manaka, M.Kawashima, T.Kobayashi, G.Imokawa: "The role of epidermal endothelin cascade in the hyperpigmentation mechanism of lentigo senilis"J.Invest. Dermatol.. 116・4. 571-577 (2001)

S.Kadono、I.Manaka、M.Kawashima、T.Kobayashi、G.Imokawa：“表皮内皮素级联在老年雀斑色素沉着过度机制中的作用”J.Invest. 116・4。 2001）