The effect of the hepatic blood flow on the amount of asialoglycoprotein receptors and the liver function.

肝血流量对脱唾液酸糖蛋白受体数量和肝功能的影响。

• 批准号: 12670893
• 负责人: FUJIMORI Kenji
• 金额: $ 1.66万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670893/
• 关键词: Liver function; Asialoglycoprotein; Tc-99m-GSA; アシアロ糖タンパク

^<99m>Tc-galactosyl human serum albumin (GSA) bounds an asialoglycoprotein receptor on the cell surface of hepatocyte and there seem to be two major factors which influence the liver uptake of ^<99m>Tc-GSA : the amount of receptors and the blood flow. ^<99m>Tc-GSA distributes homogeneously in the non-tumorous liver tissue, however, there are some cases to show focal decreased uptake in these tissues. Theoretical analysis was performed with the non-linear compartment model including blood flow and receptor amount to reveal the factors influencing liver uptake.To evaluate the model feasibility, an animal model (rat) for a partial hepatic artery or portal vein ligation procedure has been tried to establish. Due to technical difficulties to monitor regional ^<99m>Tc-GSA concentration in the liver, no concrete result has been yet achieved in this term.

人<99m>血清白蛋白（GSA）与肝细胞表面的去唾液酸糖蛋白受体结合，影响肝摄取GSA的主要因素有两<99m>个：受体数量和血流量。Tc-GSA<99m>在非肿瘤性肝组织中均匀分布，然而，在某些情况下显示这些组织中的局灶性摄取减少。采用包含血流量和受体量的非线性房室模型对影响肝摄取的因素进行理论分析，并尝试建立部分肝动脉或门静脉结扎的动物模型（大鼠），以评价该模型的可行性。由于监测肝脏中局部13 Tc-GSA浓度的技术困难<99m>，在这一时期尚未取得具体结果。

项目成果

Fujimori K, Ichimura K, Hirokawa N, Takeda M, Yama N, et al.: "Segmental Decreased Uptake of 99mTc-labeld Galactosyl-Neoglycoalbumin in Non-tumorous Liver Tissue : Sensitivity Analysis of the Factors Inf1uencin~ Liver Uptake with Non-Linear Compartment Mo

Fujimori K、Ichimura K、Hirokawa N、Takeda M、Yama N 等人：“非肿瘤肝组织中 99mTc 标记的半乳糖基新糖白蛋白的分段摄取减少：影响非线性肝摄取因素的敏感性分析

Fujimori K, Satoh T, Yama N, Hareyama M.: "Feasibility evaluation of 99mTc-GSA early-phase index -Is it possible to estimate liver function with a short-term acquisition ?"J Nucl Med.. 42. 328 (2001)

Fujimori K、Satoh T、Yama N、Hareyama M.：“99mTc-GSA 早期指数的可行性评估 - 是否可以通过短期采集来估计肝功能？”J Nucl Med.. 42. 328 (2001

藤森 研司, 庄内 孝春, 小井戸 一光, 吉田 悟, 武田 美貴, 山 直也 他: "非線形3コンパートメントモデルによる99mTc-GSA受容体量の推定-採血を要しない受容体結合型モデル-"核医学. 36. 753-760 (1999)

Kenji Fujimori、Takaharu Shonai、Kazumitsu Koido、Satoru Yoshida、Miki Takeda、Naoya Yama 等人：“使用非线性三室模型估算 99mTc-GSA 受体量 - 不需要采血的受体耦合模型 -”核医学。36.753-760（1999）

Fujimori K, Ichimura K, Takeda M, Yama N, Yoshida S, et al.: "Focal decreased uptake of Tc-99m-labeld galactosyl-neoglycoalbumin in non-tumorous liver tissue : analyzingthe factors influencing liver uptake with non-linear 4-compartment model"Eur J Nucl Me

Fujimori K、Ichimura K、Takeda M、Yama N、Yoshida S 等人：“非肿瘤肝组织中 Tc-99m 标记的半乳糖基新糖白蛋白的摄取局部减少：用非线性 4- 分析影响肝脏摄取的因素

Fujimori K, Shounai T, Koito M, Yoshida S, Takeda M, Yama N, et al.: "Estimation of 99mTc-GSA receptor amount by non-linear 3-caomprtment model : Ligand-receptor binding model without blood sampling."Kaku-Igaku Gaku. 36. 753-760 (1999)

Fujimori K、Shounai T、Koito M、Yoshida S、Takeda M、Yama N 等人：“通过非线性 3-caomprtment 模型估算 99mTc-GSA 受体量：无需采血的配体-受体结合模型。”Kaku