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Development and verification of new agent ^<99m>Tc-technenano-colloid for lymphoscintigraphy

淋巴闪烁显像新剂^<99m>Tc-technenano-colloid的开发与验证

基本信息

批准号：
12670906
负责人：
UCHIYAMA Mayuki
金额：
$ 0.64万
依托单位：
JIKEI UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2002
项目状态：
已结题

项目摘要

Lymphoscintigraphy has been attracted for the reason of sentinel node concept for malignant melanoma or breast cancer. We don't have the agent with best particle size for lymphoscintigraphy in this countory. We have tried to develop new agent, ^<99m>Tc-technenano-colloid with best size of particle. We made the new equipment which collected ^<99m>Tc-technegas into saline solution and named it the impinger of Jikei University Style. We verified the size, uniformity, bonding of the particle.We tried to perform lymphoscmtigraphy with ^<99m>Tc-technenano-colloid to rabbits and observed the lymphatic basin and accumulation in lymph nodes. "Lymphatic mapping and sentinel node biopsy in patient with breast cancer for determination axillary lymph node disection" In cooperation with Department of Surgery, we have performed lympatic mapping and sentinel node scintigraphy to assess, first whether a single axillary node (sentinel node) initially receives malignant cells from a breast carcinoma and second whether a clear sentinel node reliably forecasts a disease-free axilla.In consecutive series with operative breast carcinoma, we injected ^<99m>Tc-phytate subdermally close to the tumor site, on the day before surgery, and scintigraphic images of the axilla and breast were taken. The sentinel node was performed intraoperative pathological examination. There were no "skip" metastases defined as a sentinel node that tested negative with higher nodes that tested positive. We have developed the new shield for sentinel lymph node scintigraphy to get better image and improve detectability of sentinel lymph node. This new shield is covered the injection site easily to prevent shine thrbugh. We developed our own examination method;-Simultaneous marking method.

由于恶性黑色素瘤或乳腺癌的前哨淋巴结的概念，淋巴核素扫描引起了人们的关注。在这个国家，我们没有最适合做淋巴核素扫描的试剂。我们尝试开发出具有最佳颗粒大小的新型试剂--99M&GT；TC-技术基胶。我们制作了将~(99m)T；~(99)T；~(99)Tc-技术气体收集到盐水溶液中的新设备，并将其命名为Jikei University式的撞击器。我们验证了颗粒的大小、均匀性、粘附性，并尝试用~(99m)T；~(99m)GT；~(99)Tm；~(39)Tm~(-1)对兔进行淋巴示踪，观察淋巴凹陷和在淋巴结中的聚集。“乳腺癌患者的淋巴定位和前哨淋巴结活检确定腋窝淋巴结清扫”我们与外科合作进行了淋巴定位和前哨淋巴结核素扫描，以评估第一个单个腋窝淋巴结(前哨淋巴结)最初是否接受乳腺癌的恶性细胞，第二个明确的前哨淋巴结是否可靠地预测无病腋窝。在连续一系列的乳腺癌手术中，我们在手术前一天在靠近肿瘤部位的皮下注射99m&GT；Tc-植酸盐，并拍摄腋窝和乳房的闪烁图像。前哨淋巴结行术中病理检查。没有“跳跃性”转移被定义为检测为阴性的前哨结节，而较高的结节检测为阳性。为了获得更好的图像，提高前哨淋巴结的探测率，我们开发了新型前哨淋巴结核素扫描屏蔽物。这种新的防护罩可以很容易地覆盖注射部位，防止闪光通过。我们开发了自己的考试方法；-同步评分法。