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Assessment of venous flow and venous-valve function in lower extremity by ultrasound - determination of risk factor for venous disease -

通过超声评估下肢静脉流量和静脉瓣膜功能 - 确定静脉疾病的危险因素 -

基本信息

批准号：
12670908
负责人：
HOSAKA Junro
金额：
$ 0.7万
依托单位：
Nippon Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

项目摘要

1 In lower extremities, venous flow and the effect of respiration and peritoneal pressure on it, and the role of venous valve were assessed. Ten lower extremities from 10 healthy volunteers were included in this study. In reverse-Trendelenburg position, veins of whole lower extremity were examined by ultrasound (US). Visualization rates of valves, venous flow and valve movement during normal respiration and those changing when peritoneal pressure increased were assessed. All valves in the whole lower extremities were satisfactorily visualized ; thus, venous flow and valve movement were easily assessed. Venous flow sympathized with respiration during normal respiration and no adverse flow at the site of the valves was observed even when peritoneal pressure increased. In conclusion, venous flow and valve movement in the whole lower extremity were satisfactorily assessed by ultrasound. The effect of respiration on the venous low and the role of the valves to prevent adverse flow were considered large.2 The relationship between venous-valve dysfunction and venous disease was assessed. Nine patients with deep venous thrombosis (DVT) and 6 patients with varicose veins (VV) were included in this study. All thrombi and varicose veins were confirmed by venograms. The methods used were similar to those adopted in the previous study. In all cases except 1 case of DVT, disappearance or shortening of valve was observed consistently (P<0.01 against normal control). Valve movement was always unclear. When peritoneal pressure increased, adverse flow lasting for more than 1 second was observed consistently (P<0.01), and area in a cross section of vein just below the valve increased remarkably in 3 of 6 cases of DVT (P=0.2) and 4 of 4 cases of VV (P=0.01). In conclusion, valve dysfunction should be associated with venous disease.3 According to these results, US is the first choice of examination for DVT/VV in our hospital and is also used frequently to assess post-operation DVT.

1测定下肢静脉血流量，呼吸、腹腔压对下肢静脉血流量的影响，以及静脉瓣的作用。本研究包括10名健康志愿者的10条下肢。取反头低脚高位，超声检查全下肢静脉。评估正常呼吸时瓣膜、静脉血流和瓣膜运动的可视化率以及腹膜压升高时的变化。整个下肢的所有瓣膜均显示良好;因此，易于评估静脉血流和瓣膜运动。正常呼吸时，静脉血流与呼吸交感，即使腹膜压升高，瓣膜部位也未观察到逆流。总之，超声对整个下肢的静脉血流和瓣膜运动进行了满意的评估。呼吸对静脉低压的影响和瓣膜防止逆流的作用被认为是很大的。2评估了静脉瓣膜功能障碍和静脉疾病之间的关系。本研究包括9例深静脉血栓形成（DVT）患者和6例静脉曲张（VV）患者。所有血栓和静脉曲张均经静脉造影证实。所采用的方法与以前的研究中所采用的方法相似。除1例深静脉血栓形成外，其余病例瓣膜均消失或缩短（与正常对照组比较P<0.01）。瓣膜运动始终不清楚。当腹膜压升高时，持续时间大于1 s的逆流持续存在（P<0.01），6例DVT中3例（P=0.2），4例VV中4例（P=0.01），瓣膜下静脉截面面积明显增大。总之，瓣膜功能障碍应与静脉疾病有关。3根据这些结果，超声是我院DVT/VV的首选检查方法，也经常用于评估术后DVT。