The late effect of intravenous laser radiation and establishment of laser surgery method for varicose vein in lower extremity

静脉激光照射治疗下肢静脉曲张的后期疗效及激光手术方法的建立

• 批准号: 17591295
• 负责人: HOSAKA Junro
• 金额: $ 1.22万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591295/
• 关键词: varicose veins; laser treatment; intervention; day surgery; レーザー; 血管内治療

Usual method for complete treatment of varicose veins in lower extremity has been a stripping surgery of saphenous vein. Laser radiation in the venous lumen may have a potential to be a lower invasive therapy. Principle of venous occlusion after laser radiation is thrombotic occlusion caused by injury on venous wall.We performed in vivo experiment using 6 pigs weighing approximately 40kg. The animals were divided in 2 groups. In one group, bandage was used around abdomen after laser radiation of an epigastric vein. In another group, no bandage was used. Laser radiation was performed at energy of 10W. After two weeks, the animals were sacrificed and the veins were analyzed microscopically. All veins were occluded immediately after laser radiation. Thrombi obtained in the group using bandage tended to be stronger (without micro-canal), compared to those obtained in another group.After animal experiment, laser radiation was performed in great saphenous veins in patient with varicose veins. The patients were divided in 2 groups. In one group, only compression stocking was used after treatment. In another group, compression pad was also used. The rates of venous occlusion in 2 groups were same. The rate of bruising after treatment was much lower in the group with compression pad.The laser energy at 10W and 14W were also adopted and rate of venous occlusion and bruising were compared.The rates of venous occlusion in 2 groups were same. The rate of bruising after treatment was much lower when adopting 10W.In conclusion, we believe that laser treatment of great saphenous vein in patient with varicose veins may be an optimal when adopting 10W and using compression pad with compression stocking.

大隐静脉剥脱术一直是治疗下肢静脉曲张的有效方法。静脉腔内的激光辐射可能具有成为低侵入性治疗的潜力。激光照射后静脉闭塞的原理是静脉壁损伤引起的血栓性闭塞，我们用6头体重约40公斤的猪进行了体内实验。将动物分为2组。在一组中，在激光照射上腹部静脉后，在腹部周围使用绷带。在另一组中，没有使用绷带。以10W的能量进行激光辐射。两周后，处死动物，用显微镜分析静脉。所有静脉在激光照射后立即闭塞。结果：1.用绷带组血栓形成强度明显高于另一组（无微通道）。2.动物实验后，对曲张静脉患者的大隐静脉进行激光照射。患者分为2组。在一组中，治疗后仅使用压缩袜。另一组同时使用加压垫。两组静脉闭塞率相同。采用10W和14W激光能量，比较两组治疗后静脉阻塞率和静脉挫伤率，两组静脉阻塞率相同。结论：采用10W激光治疗大隐静脉曲张，并配合使用加压垫和加压袜，是治疗大隐静脉曲张的最佳选择。

项目成果

下肢静脈瘤のIVR(1) レーザー治療

下肢静脉曲张的IVR（一）激光治疗

• 发表时间: 2007
• 期刊: 臨床画像 23・2
• 作者: Ohmuraya;M.;東野 博;S.Shimohara;東野 博;M.Ohmuraya;荒木 正健;Kazuhiko Masuda;Hiromitsu Hayashi;Hiromitsu Hayashi;保坂 純郎;保坂 純郎
• 通讯作者: 保坂 純郎

下肢静脈瘤の最新治療法:endovenous laser treatment(EVLT)の初期治療成績

静脉曲张最新治疗方法：静脉内激光治疗（EVLT）初步治疗结果

• 发表时间: 2005
• 期刊: 日本医科大学医学会雑誌 1(1)
• 作者: 日高史貴;保坂純郎;田島廣之;小野澤志郎;隈崎達夫
• 通讯作者: 隈崎達夫

Endovenous laser treatment for varicose veins : An effect of laser energy on venous occlusion and minor complications

静脉内激光治疗静脉曲张：激光能量对静脉闭塞和轻微并发症的影响

• 发表时间: 2007
• 期刊: Jpn. J. Phlebol 18(1)
• 作者: Ohmuraya;M.;東野 博;S.Shimohara;東野 博;M.Ohmuraya;荒木 正健;Kazuhiko Masuda;Hiromitsu Hayashi;Hiromitsu Hayashi;保坂 純郎;保坂 純郎;Junro H
• 通讯作者: Junro H

EVLT(endovenous laser treatment) : 出力の血管閉塞率と合併症に及ぼす影響

EVLT（静脉内激光治疗）：输出量对血管闭塞率和并发症的影响

• 发表时间: 2007
• 期刊: 静脈学 18・1
• 作者: Ohmuraya;M.;東野 博;S.Shimohara;東野 博;M.Ohmuraya;荒木 正健;Kazuhiko Masuda;Hiromitsu Hayashi;Hiromitsu Hayashi;保坂 純郎
• 通讯作者: 保坂 純郎

Interventional radiology for varicose veins in lower extremity (1) : endovenous laser treatment

下肢静脉曲张的介入放射学（一）：静脉内激光治疗

• 发表时间: 2007
• 期刊: Clinical Imagiology 23(2)
• 作者: Ohmuraya;M.;東野 博;S.Shimohara;東野 博;M.Ohmuraya;荒木 正健;Kazuhiko Masuda;Hiromitsu Hayashi;Hiromitsu Hayashi;保坂 純郎;保坂 純郎;Junro H;Yoshioka Kunihiro;Junro H
• 通讯作者: Junro H