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Parallel distributed processing neuroimaging in schizophrenia during frontal tasks

额叶任务期间精神分裂症的并行分布式处理神经影像

基本信息

批准号：
12670936
负责人：
KAZUHIEO shinosaki
金额：
$ 2.24万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2002
项目状态：
已结题

项目摘要

Parallel-distributed processing neuroimaging was studied in normal control, schizophrenic patients with auditory hallucination (AH) and without AH by using MEG (magnetoencephalography) and synthetic aperture magnetometry (SAM) analysis. In the Stroop color word interference task, the total reaction time was set at 650ms with a time window of 20ms in steps of 50ms. Neural activation began in the left posterior parietal-occipital area (150-250 ms post-stimulus), followed by the right prefrontal polar area (250-350 ms), the left dorsolateral prefrontal cortex (DLPFC, 250-400 ms), and the mid-to lower-primary motor area (350-400 ms). Successive and temporally overlapping activation of various cortical regions were successfully estimated with a short 200 ms time interval, contrary to previous PET and fMRI studies. The left DLPFC in patients without AH showed smaller activation than that in the control group. The left DLPFC in patients with AH showed no significant activation. These results were consistent with the hypofrontality hypothesis in schizophrenic patients and showed that dysfunction in the left DLPFC in schizophrenia with AH might be more remarkable than that in schizophrenia without AH. In word generation (Shiritori) task, significant activation in the left DLPFC was estimated in all patients, while not in most of controls. Significant activation in the left posterior superior temporal gyrus (STG) was estimated in most of controls, while not in any patients. These results showed the functional impairment between the linguistic process in the STG and the organization-control process in the DLPFC in schizophrenic patients.

应用脑磁图(MEG)和合成孔径磁测法(SAM)对正常对照组、精神分裂症伴幻听(AH)和不伴AH的精神分裂症患者进行了平行分布处理的神经成像研究。在Stroop颜色词干扰任务中，总反应时设置为650ms，时间窗为20ms，以50ms为步长。神经活动开始于左侧顶枕后区(刺激后150~250ms)，其次是右侧前额极区(250~350ms)、左侧背外侧前额叶(DLPFC，250~400ms)和中下初级运动区(350~400ms)。与之前的PET和fMRI研究相反，在短的200ms时间间隔内，成功地估计了不同皮质区域的连续和时间重叠的激活。无AH组左侧DLPFC的激活程度低于对照组。AH患者左侧DLPFC无明显激活。这些结果与精神分裂症患者额叶功能低下的假说相一致，提示伴AH的精神分裂症患者的左侧DLPFC功能障碍可能比无AH的精神分裂症患者更为显著。在单词生成(Shiritori)任务中，所有患者的左侧DLPFC都有显著的激活，而大多数对照组没有。据估计，大多数对照组的左侧后颞叶上回(STG)有显著的激活，而没有任何患者。这些结果表明，精神分裂症患者STG中的语言加工和DLPFC中的组织控制加工之间存在功能障碍。