Regulation of HDL receptor SR-B1 and its role on lipid metabolism

HDL受体SR-B1的调节及其对脂质代谢的作用

• 批准号: 12671127
• 负责人: MAKOTO Kinoshita
• 金额: $ 1.79万
• 依托单位: TEIKYO UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671127/
• 关键词: SR-B1; bile acid; resin; HDL; 受容体

Scanenger receptor type B1 (SR-B1) is an unique receptor of HDL which uptake cholesteryl ester from HDL. Therefore, mouse which overexpress SR-B1 mRNA showed low HDL cholesterol concentration. In despite of low HDL cholesterol concentration, mouse which overexpress SR-B1 mRNA showed resistance against atherosclerotic formula diet.In our study, it was revealed that SR-B1 remodulate the large HDL that were observed in CETP deficient patient into normal HDL particle. And the expression of SR-B1 mRNA of liver was increased according to the amount of bile acid secretion. It may be concluded that SR-B1 may change the atherogenic large HDL into normal anti-atherogenic HDL.

B1型扫描受体（Scanner receptor type B1，SR-B1）是高密度脂蛋白（HDL）的一种独特受体，能从HDL中摄取胆固醇酯。因此，过表达SR-B1 mRNA的小鼠显示低HDL胆固醇浓度。在我们的研究中发现，SR-B1 mRNA过表达的小鼠，尽管HDL胆固醇浓度低，但对动脉粥样硬化配方饮食表现出抵抗性。随着胆汁酸分泌量的增加，肝脏SR-B1 mRNA的表达量增加。结论：SR-B1可使致动脉粥样硬化的大HDL转变为正常的抗动脉粥样硬化的HDL。

项目成果

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M. KINOSHITA 等人：“载脂蛋白 E 加速巨噬细胞中胆固醇的流出：载脂蛋白 E 缺乏时黄瘤形成的机制”J.

Kinoshita et al: "Apolipoprotein E accelerate the efflux・・"J.Athero.Thromb.. 6. 22-27 (2000)

Kinoshita 等人：“载脂蛋白 E 加速流出……”J.Athero.Thromb.. 6. 22-27 (2000)

Kinoshita., et al.: "Apolipoprotein E accelerates the efflux--"J.Athero.Thromb. 6. 22-27 (2000)

Kinoshita., et al.：“载脂蛋白 E 加速外流——”J.Athero.Thromb.

Kinoshita et al: "Doxazoan, anα1 adrenergic anti・〜"Am J.Hypertension. 14. 267-270 (2001)

Kinoshita 等人：“多沙唑安，一种 α1 肾上腺素能抗药·〜”Am J.Hypertension 14. 267-270 (2001)

M.Kinoshita et al: "Apolipoprotein E accelate the efflux of…"J Athero.Thromb. 6. 22-27 (2000)

M. Kinoshita 等人：“载脂蛋白 E 加速……的流出”J Thromb。 6. 22-27 (2000)