Regulation of HDL receptor SR-B1 and its role on lipid metabolism

扫描受体B1 （SR-B1）是一种独特的高密度脂蛋白受体，它从高密度脂蛋白中摄取胆固醇酯。因此，过表达SR-B1 mRNA的小鼠HDL -胆固醇浓度较低。尽管高密度脂蛋白胆固醇浓度较低，但SR-B1 mRNA过表达的小鼠对动脉粥样硬化配方饮食表现出抵抗性。在我们的研究中发现，SR-B1可以将CETP缺乏患者中观察到的大HDL调节为正常的HDL颗粒。肝脏SR-B1 mRNA的表达随胆汁酸分泌量的增加而升高。由此可见，SR-B1可使致动脉粥样硬化大HDL变为正常的抗动脉粥样硬化HDL。

Scanenger receptor type B1 (SR-B1) is an unique receptor of HDL which uptake cholesteryl ester from HDL. Therefore, mouse which overexpress SR-B1 mRNA showed low HDL cholesterol concentration. In despite of low HDL cholesterol concentration, mouse which overexpress SR-B1 mRNA showed resistance against atherosclerotic formula diet.In our study, it was revealed that SR-B1 remodulate the large HDL that were observed in CETP deficient patient into normal HDL particle. And the expression of SR-B1 mRNA of liver was increased according to the amount of bile acid secretion. It may be concluded that SR-B1 may change the atherogenic large HDL into normal anti-atherogenic HDL.