Prevention of the total hip arthroplasty loosening polyethylene liner coated with MPC polymer

MPC聚合物涂层聚乙烯内衬预防全髋关节置换术松动

• 批准号: 12671398
• 负责人: SATOH Wakyo
• 金额: $ 2.18万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671398/
• 关键词: Biomaterials; total hip arthroplasty; loosening; osteolysis; 2-メタクリロイルオキシエチルホスホリルコリン(MPC); 股関節; 人工股関節全置換術; 股関節シュミレーター; 骨融解; 破骨細胞; サイトカイン

Periprosthetic bone resorption is a serious problem associated with aseptic loosening of total hip prosthesis. A foreign body reaction of synovial tissues and macrophages to wear debris released into the joint space by friction between the polyethylene component and the metal head has been suggested as a common pathological finding in patients with loosening of their prosthesis.The purpose of this study is prevention of the loosening of the total hip prosthesis, by using polyethylene component coated with 2-methacryloxyethyl phosporylcholine (MPC) polymer. We acquired the knowledge shown in the following through this study.1. Friction and the torque of the polyethylene surface coated with MPC polymer reduced to 20% of that of non-coated polyethylene surface. And wear particle of the polyethylene component reduced by coating with MPC polymer.2. MPC particles could avoid from phagocyted by macrophages. This phenomenon shows that the MPC particles were not recognized as oreign body by reticulo-endotherial system.3. The concentration of cytokines, which are produced by macrophages that phagocytize wear particle and stimulate osteoclastic bone resoption are much lower in the MPC coated polymer group than the non-coated group. This phenomenon suggests that the MPC particles are not stimulate osteoclastic bone resoption.

假体周围骨吸收是全髋关节假体无菌性松动的重要原因。滑膜组织和巨噬细胞对聚乙烯部件和金属股骨头之间摩擦释放到关节间隙中的磨损碎屑的异物反应已被认为是假体松动患者的常见病理学发现，本研究的目的是通过使用涂有2-甲基丙烯酰氧乙基磷酰胆碱（MPC）聚合物的聚乙烯部件来预防全髋关节假体松动。通过本研究，我们获得了以下知识.涂覆MPC聚合物的聚乙烯表面的摩擦和扭矩降低到未涂覆聚乙烯表面的20%。并且通过涂覆MPC聚合物减少了聚乙烯部件的磨损颗粒. MPC颗粒可以避免被巨噬细胞吞噬。这一现象表明MPC颗粒没有被网状-内皮系统识别为外来体.在MPC涂覆的聚合物组中，由吞噬磨损颗粒并刺激骨吸收的巨噬细胞产生的细胞因子的浓度比未涂覆的组低得多。这种现象表明MPC颗粒不刺激骨细胞骨吸收。

项目成果

Tomohiro Konno: "Blood compatible nanoparticles immobilized with 2-Methacrylogy oxyethyl phosphoryl choline polymer"Transactions of the Materials Research Society of Japan. 26(3). 897-900 (2001)

Tomohiro Konno：“用 2-Methacrylogy 氧乙基磷酰胆碱聚合物固定的血液相容性纳米颗粒”，日本材料研究会汇刊。

Tomohiro Konno, Kazuhiko Ishihara: "Blood compatible nanoparticles immobilized with 2- methacryloyloxyethyl phospholylcholine polymer"Transaction of the Meterials Research of Japan. 26(3). 897-900 (2001)

Tomohiro Konno、Kazuhiko Ishihara：“用 2-甲基丙烯酰氧基乙基磷酰胆碱聚合物固定的血液相容性纳米颗粒”日本材料研究会刊。

Tomohiro Konno: "Blood compatible nanoparticle immobilized with 2-methacryloxyl phosphorylcholine polymer"Transaction of the materials Research Society of Japan. 26(3). 897-900 (2001)

Tomohiro Konno：“固定有2-甲基丙烯酰氧基磷酰胆碱聚合物的血液相容性纳米颗粒”日本材料研究会学报。

茂呂 徹: "生体膜類似構造を持つMPCの人工関節への応用に関する検討-MPCポリマーはポリエチレンライナーの磨耗を低減するー"日本整形外科学会雑誌. 76(3). 5150 (2002)

Toru Moro：“具有类生物膜结构的 MPC 在人工关节中的应用研究 - MPC 聚合物减少聚乙烯内衬的磨损”，日本骨科学会杂志 76(3)。