Neural mechanism of respiratory signal during general anesthesia

进行了几项临床和基础研究项目，从而显示了以下发现：1）喉镜观察显示了人类打嗝时声门闭合的主动过程。2）咪达唑仑镇静期间，鼻途径上游段的呼吸功增加，氟马西尼拮抗后恢复至基线。3）坦度螺酮，10和30 mg，安全地降低择期耳鼻喉科手术患者的术前焦虑程度，与口服地西泮10 mg相似。4）在全麻下接受鼓室成形术的患者中，口服坦度螺酮术前用药可有效预防术后恶心和呕吐。5）我们提出了一个系统发育的角度，揭示了一个新的光打嗝的起源和生理意义。

Several clinical and basic research projects were performed, thereby exhibiting the following findings.1) Laryngoscopic observation revealed an active process in glottic closure during hiccups in human.2) The work of breathing spent on the upstream segment of the nasal route increased during midazolam sedation and returned to baseline after flumazenil antagonism.3) Tandospirone, 10 and 30 mg, safely reduced preoperative anxiety to a similar extent as oral diazepam 10 mg in patients undergoing elective otolaryngologic surgery.4) Premedication with oral tandospirone is effective against postoperative nausea and vomiting in patients undergoing tympanoplasty under general anesthesia.5) We proposed a phylogenetic perspective that sheds a new light on the origin and physiological significance of hiccups.