Developing Active Stimulation and Monitoring Technologies to Optimize Pain and Nociception Management During Regional Anesthesia, General Anesthesia, and Post-Operative Care

开发主动刺激和监测技术,以优化区域麻醉、全身麻醉和术后护理期间的疼痛和伤害感受管理

基本信息

  • 批准号:
    10604993
  • 负责人:
  • 金额:
    $ 47.44万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-09-19 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

Project Summary Surgery and acute post-operative pain are major contributors to persistent pain, chronic pain, and opioid dependence. Currently, there are no products on the market in the United States that can be used to monitor surgical nociception. Existing products use indicators that are susceptible to intraoperative influences such as blood loss, anesthetic drugs and antihypertensives. This leaves anesthesiologists to guess whether or not the analgesic therapies they are providing will be effective at managing intra-operative nociception and subsequent post-operative pain. A significant fraction of surgeries also rely on regional anesthesia techniques, and, these techniques are not foolproof, and may fail during surgery, leading to potentially uncontrolled postoperative pain that is apparent only when the patient recovers consciousness after surgery in intense pain. As it stands, anesthesiologists have no way to directly assess the ongoing efficacy of their regional blocks, leading to unreliable nociception and pain management. Therefore, improved methods to monitor surgical nociception are clearly needed. This project proposes to develop new technology that makes it possible for the first time to use event-related potentials (ERPs) to actively assess pain and analgesia during general and regional anesthesia. ERPs are generated by painful stimuli and can be measured at the scalp by averaging waveforms from repeated stimuli generated by a variety of methods including electrical stimulation. ERPs are challenging if not impossible to use for anesthesia monitoring because they are very small, between ~1 to 10 microvolts, and are overshadowed by background electroencephalogram oscillations that are 10- to 100-fold larger in amplitude during general anesthesia or sedation. Recently, we developed a novel technology for processing ERPs that increases their precision ~150-fold even in the presence of orders-of-magnitude larger background oscillations. Using this knowledge, we propose to develop this technology for commercial use in a “Fast-Track” STTR project.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Tuan Le Mau其他文献

Tuan Le Mau的其他文献

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{{ truncateString('Tuan Le Mau', 18)}}的其他基金

Developing a novel system combining cognitive assessment with PASCALL FDA-cleared intraoperative anesthesia EEG brain monitor to prevent postoperative neurocognitive disorders in aging patients
开发一种将认知评估与 FDA 批准的 PASCALL 术中麻醉脑电图脑监测仪相结合的新型系统,以预防老年患者术后神经认知障碍
  • 批准号:
    10760816
  • 财政年份:
    2023
  • 资助金额:
    $ 47.44万
  • 项目类别:
Personalized anesthetic brain monitoring: Developing novel systems, sensors, and algorithms for aging, dementia, and Alzheimers disease patients
个性化麻醉大脑监测:为衰老、痴呆和阿尔茨海默病患者开发新型系统、传感器和算法
  • 批准号:
    10360566
  • 财政年份:
    2021
  • 资助金额:
    $ 47.44万
  • 项目类别:
Personalized anesthetic brain monitoring: Developing novel systems, sensors, and algorithms for aging, dementia, and Alzheimers disease patients
个性化麻醉大脑监测:为衰老、痴呆和阿尔茨海默病患者开发新型系统、传感器和算法
  • 批准号:
    10303200
  • 财政年份:
    2021
  • 资助金额:
    $ 47.44万
  • 项目类别:
Developing novel technologies to monitor nociception and opioid administration during surgery and general anesthesia in order to minimize post-operative opioid requirements
开发新技术来监测手术和全身麻醉期间的伤害感受和阿片类药物的给药,以尽量减少术后阿片类药物的需求
  • 批准号:
    10595838
  • 财政年份:
    2020
  • 资助金额:
    $ 47.44万
  • 项目类别:
Developing novel technologies to monitor nociception and opioid administration during surgery and general anesthesia in order to minimize post-operative opioid requirements
开发新技术来监测手术和全身麻醉期间的伤害感受和阿片类药物的给药,以尽量减少术后阿片类药物的需求
  • 批准号:
    10157621
  • 财政年份:
    2020
  • 资助金额:
    $ 47.44万
  • 项目类别:
Personalized anesthetic brain monitoring: Developing novel systems, sensors, and algorithms for aging, dementia, and Alzheimers disease patients
个性化麻醉大脑监测:为衰老、痴呆和阿尔茨海默病患者开发新型系统、传感器和算法
  • 批准号:
    9909360
  • 财政年份:
    2020
  • 资助金额:
    $ 47.44万
  • 项目类别:
Developing novel technologies to monitor nociception and opioid administration during surgery and general anesthesia in order to minimize post-operative opioid requirements
开发新技术来监测手术和全身麻醉期间的伤害感受和阿片类药物的给药,以尽量减少术后阿片类药物的需求
  • 批准号:
    10654060
  • 财政年份:
    2020
  • 资助金额:
    $ 47.44万
  • 项目类别:

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