Application study of High Intensity Focused Ultrasound for renal tumor

近年来研制的高强度聚焦超声（HIFU）系统将超声的能量急剧聚焦并转化为热能。剧烈的热脉冲导致立即凝固性坏死。HIFU治疗肾肿瘤的效果已被提出。然而，HIFU在肿瘤中的潜在应用提出了关于精确消融、监测方法、剩余活肿瘤细胞和安全性的问题。没有这样详细的评价报告。因此，我们评估了兔肾VX2癌的这些问题。hifu治疗体积与凝固性坏死体积有统计学意义（r=0.84）。实验过程中未见出血及生命体征改变。结果表明，兔模型HIFU消融准确，监测方法良好，治疗安全性高。在不适当的治疗条件下，HIFU没有完全破坏肿瘤，但在适当的治疗条件下，治疗区域内未观察到残留的活肿瘤细胞。总之，这些结果表明HIFU治疗肾肿瘤将是一个令人着迷的临床应用。

Recently developed High Intensity Focused Ultrasound(HIFU) system focuses sharply and converts the energy of the ultrasound into heat. The sharp heat impulse leads to an immediate coagulative necrosis. The effect of HIFU treatment on the renal tumor has been suggested. However, the potential use of HIFU for tumor raises the issue regarding precise ablation, monitoring method, residual viable tumor cells, and safety. No such detailed evaluation has been reported. Therefore, we evaluated these issues in rabbit kidney bearing VX2 carcinoma. HIFU-treated volume statistically significantly correlated with coagulative necrosis volume(r=0.84). In experimental procedure, bleeding and the change of vital sign were not observed. Our results showed the precise ablation, good monitoring method and safety of HIFU treatment in rabbit model. Under inappropriate treatment condition, no tumor was completely destroyed by HIFU, but under appropriate condition no residual viable tumor cell was observed inside the treated areas. In summary, these results demonstrate that HIFU treatment of renal tumor would be a fascinating clinical application.