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Application study of High Intensity Focused Ultrasound for renal tumor

高强度聚焦超声在肾肿瘤中的应用研究

基本信息

批准号：
12671545
负责人：
NISHI Kazuhiko
金额：
$ 2.24万
依托单位：
Kumamoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671545/
关键词：
HIFU Renat tumor Safety Effect 長期効果生存率

项目摘要

Recently developed High Intensity Focused Ultrasound(HIFU) system focuses sharply and converts the energy of the ultrasound into heat. The sharp heat impulse leads to an immediate coagulative necrosis. The effect of HIFU treatment on the renal tumor has been suggested. However, the potential use of HIFU for tumor raises the issue regarding precise ablation, monitoring method, residual viable tumor cells, and safety. No such detailed evaluation has been reported. Therefore, we evaluated these issues in rabbit kidney bearing VX2 carcinoma. HIFU-treated volume statistically significantly correlated with coagulative necrosis volume(r=0.84). In experimental procedure, bleeding and the change of vital sign were not observed. Our results showed the precise ablation, good monitoring method and safety of HIFU treatment in rabbit model. Under inappropriate treatment condition, no tumor was completely destroyed by HIFU, but under appropriate condition no residual viable tumor cell was observed inside the treated areas. In summary, these results demonstrate that HIFU treatment of renal tumor would be a fascinating clinical application.

高强度聚焦超声（High Intensity Focused Ultrasound，HIFU）是近年来发展起来的一种超声聚焦技术。急剧的热脉冲导致立即凝固性坏死。HIFU治疗肾肿瘤的效果已被提出。然而，高强度聚焦超声在肿瘤治疗中的潜在应用提出了关于精确消融、监测方法、残余存活肿瘤细胞和安全性的问题。没有报告过这种详细的评价。因此，我们评估了携带VX 2癌的兔肾中的这些问题。HIFU治疗体积与凝固性坏死体积在统计学上显著相关（r=0.84）。实验过程中未见出血及生命体征变化。本研究结果表明，HIFU治疗家兔模型具有精确的消融效果、良好的监测手段和安全性。在不适当的治疗条件下，没有肿瘤被HIFU完全破坏，但在适当的条件下，治疗区域内没有观察到残留的活肿瘤细胞。总之，这些结果表明，HIFU治疗肾肿瘤将是一个迷人的临床应用。