The effects of arachidonic acid on urological tumors
The effects of arachidonic acid on urological tumors
批准号:
12671544
负责人:
KOGA Shigehiko
金额:
$2.11万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2000
资助国家:
日本
项目状态:
已结题
起止时间:
2000 至 2002
中文摘要
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英文摘要
We investigated the effects of arachidonic acid on urological tumors.1. Cyclooxygenase (COX)-2 plays an important role in tumor cell proliferation, resistant to apoptosis, angiogenesis, and invasion in various malignant tumors. Of 131sections of renal cell carcinoma (RCC), 70(53.4%) were positive for COX-2 expression. COX-2 expression was correlated with Ki-67 labeling index, microvessel density, and MMP-2 expression.2. RCC with sarcomatoid component which has a highly malignant biological behavior. We evaluated 19 sections with sarcomatoid and non-sarcomatoid component. In regard to sarcomatoid component, 15 (78.9%) were positive for COX-2, which showed diffuse staining of tumor cell cytoplasm. In contrast, in regard to non-sarcomatoid component, 8 (42.1%) were positive for COX-2. COX-2 expression was significantly increased in sarcomatoid component compared with non-sarcomatoid component (P=0.02).
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Miyata Y, Koga S, et al.: "Relationship between serum ferritin levels and tumour status in patients with renal cell carcinoma"BJU Int. 88. 974-977 (2001)
Miyata Y,Koga S,等:“肾细胞癌患者血清铁蛋白水平与肿瘤状态之间的关系”BJU Int。
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Sakaguchi M, Kubota S, Nishikido M, Taniguchi K, Inuzuka S, Saito Y, Kanetake H, Koga S: "The effectors of killer activity induced by interferon-alpha and gamma in peripheral blood mononuclear cells"Int J Mol Med. 10. 317-320 (2002)
Sakaguchi M、Kubota S、Nishikido M、Taniguchi K、Inuzuka S、Saito Y、Kanetake H、Koga S:“外周血单核细胞中干扰素 α 和 γ 诱导的杀伤活性的效应器”Int J Mol Med。
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Miyata Y, Koga S, et al.: "Predictive values of acute phase reactants basic fetoprotein, and immunosuppressive acidic protein for staging and survival in renal cell carcinoma"Urology. 58. 161-164 (2001)
Miyata Y、Koga S 等人:“急性期反应物碱性胎蛋白和免疫抑制酸性蛋白对肾细胞癌分期和生存的预测价值”泌尿学。
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Miyata Y, Koga S, Nishikido M, Hayashi T, Kanetake H: "Relationship between serum ferritin levels and tumor status in patients with renal cell carcinoma"BJU Int. 88. 974-977 (2001)
Miyata Y、Koga S、Nishikido M、Hayashi T、Kanetake H:“肾细胞癌患者血清铁蛋白水平与肿瘤状态的关系”BJU Int。
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Miyata Y, Koga S, Kanada S, et al.: "Expression of cyclooxygenase-2 in renal cell carcinoma : correlation with tumor cell proliferation, apoptosis, angiogenesis, matrix metalloproteinase-2 expression, and survival"Clin Cancer Res. (in press).
Miyata Y、Koga S、Kanada S 等人:“肾细胞癌中环氧合酶 2 的表达:与肿瘤细胞增殖、凋亡、血管生成、基质金属蛋白酶 2 表达和存活的相关性”Clin Cancer Res。
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共 11 条
CLINICAL STUDY OF RENAL ANGIOMYOLIPOMA IN KYUSHU DISTRICT
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批准号:16591602
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2004
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负责人:KOGA Shigehiko
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依托单位:
The effect of nitric oxide on allograft rejection
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批准号:07671736
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:1995
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负责人:KOGA Shigehiko
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依托单位:
海外基金