Development of Resin Applying Hydrophobic Monomer and Biocompativility of The Monomer

疏水性单体树脂的研制及其生物相容性

• 批准号: 12671908
• 负责人: UMEMOTO Kozo
• 金额: $ 2.3万
• 依托单位: Kanagawa Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671908/
• 关键词: Biocompatibility; Protein; DNA Synthesis; Cytotoxicity; Synthesis; Hydrophobic Monomer; Resin Material; Mechanical Property

To improve the water sorption of PMMA, new hydrophobic monomers, such as norbonyl and phenyl methacrylate, were studied. Water sorption of the copolymers of the hydrophobic monomers and MMA decreased with in the concentration of the monomers. Various mechanical properties were increased higher than PMMA. The degree of dispersion of the hydrophobic monomer, such as 2, 2-bis[4-(2-hydroxy-3-methacryloyloxypropoxyphenyl)propane (Bis-GMA), into a medium was analyzed by HPLC. The concentration of Bis-GMA in upper part of the medium was high rather than that of lower part, and the fact showed no proper cytotoxic effect. Three dispersion mediums and two dispersing agents, to disperse the hydrophobic monomer for cytotoxic test were estimated. Those dispersion mediums studied showed no a satisfactory. The dispersing agents were not effective as a dispersing gent and had toxicity at low concentration.

为了提高PMMA的吸水性，研究了甲基丙烯酸降冰片酯和苯酯等新型疏水单体。疏水单体与MMA共聚物的吸水率随单体浓度的增加而降低。各种力学性能的提高高于PMMA。通过HPLC分析疏水性单体如2，2-双[4-（2-羟基-3-甲基丙烯酰氧基丙氧基苯基）丙烷（Bis-GMA）在介质中的分散度。Bis-GMA在培养液上部的浓度比下部高，没有显示出适当的细胞毒作用。评价了三种分散介质和两种分散剂，以分散细胞毒性试验用疏水单体。所研究的分散介质均未表现出令人满意的效果。分散剂作为分散剂效果不佳，低浓度时有毒性。