Apoptosis induces of a multi-drug resistant oral cancer cells by Tax01, Alkaroid derived ICHI
生物碱衍生的 ICHI Tax01 诱导多重耐药口腔癌细胞凋亡
基本信息
- 批准号:12671940
- 负责人:
- 金额:$ 1.73万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2000
- 资助国家:日本
- 起止时间:2000 至 2001
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
[purpose]Medical treatment by combined use of the conventional chemotheraoy, radiotherapy, a surgery treatment, etc. has been performed to the squampus cell carcinoma which has the large majority of many malignant tumor. However, you should not carry out satisfactory of the medical treatment results. Moreover, existence of the cancer cell which shows reresitance is indicated to oral domain squamous cell carcinoma by the chemotherapeutic drug used tor high frequency, and it is said that the malignant tumor which shows resistance to one chemotherapeutic drug has the so-called cross resistance ability which shows resistance to other chemotherapeutic drugs.Recently, Taxol was found out as a new anti-neoplasm agent. Taxol is the alkaloid half-compounded from the department medicinal herb of ICHII, and is a different mechanism foreword from the conventional antineoplastic drug. In this study, comparison of Taxol's anti-neoplasm effect of multi drug resistance of the oral cancer cells establi … More shed by our laboratory in serum-free culture. Moreover, the resistance mechanism of a multi drug-resistant cancer can is reported.[result and conclusion]--Taxol did not show cross resistance to NA-CDDP cells and NA-ADM cells established by our laboratory. A possibility that Taxol expressed an effect was suggested also to the case which shows resistance to CDDP and ADM by which the present clinical application is carried out. Moreover, the amount of expression of MRP-2/cMOAT in NA-CDDP cells is the amount of expression of the amount of about 4 times as compared with NA cells, and it was suggested that MRP-2/cMOAT is participating in CDDP resistance significantly. On the other hand, since there was about 12-time amount of expression of MRP-3 gene of NA-CDDP cells as compared with NA cells, the rather than thing which the transportation-cell outside ability of CDDP through MRP-3 is going up was suggested through MRP-2/cMOAT. In conclusion, it was thought that Taxol became an effective cure to a multi-drug resistance oral cancer. Moreover, it was possible by solving the resistance mechanism of a multi drug-resistant cancer cell to contribute to diagnosis of medicine susceptibility. Less
[目的]在众多恶性肿瘤中,鳞状细胞癌占绝大多数,通过常规化疗、放疗、手术治疗等的联合使用进行医学治疗。但是,你不应该进行令人满意的医疗结果。此外,口腔鳞状细胞癌中存在耐药的癌细胞,这是由高频率使用的化疗药物所指示的,并且据说对一种化疗药物显示耐药的恶性肿瘤具有对其他化疗药物显示耐药的所谓交叉耐药能力。紫杉醇(Taxol)是从ICHII类药用植物中提取的生物碱半合成物,是一种与传统抗癌药物作用机制不同的先导性药物。本研究通过建立多药耐药的口腔癌细胞系,比较紫杉醇的抗肿瘤作用, ...更多信息 是我们实验室在无血清培养中产生的。此外,还报道了一种多药耐药肿瘤的耐药机制。[结果与结论]紫杉醇对本实验室建立的NA-CDDP细胞和NA-ADM细胞无交叉耐药。紫杉醇对顺铂和阿霉素耐药的病例也有可能发挥作用,目前的临床应用就是通过这些病例进行的。此外,与NA细胞相比,NA-CDDP细胞中MRP-2/cMOAT的表达量是约4倍的表达量,并且表明MRP-2/cMOAT显著参与CDDP抗性。另一方面,由于NA-CDDP细胞的MRP-3基因的表达量是NA细胞的约12倍,因此通过MRP-2/cMOAT提示,CDDP通过MRP-3的细胞外转运能力正在上升。总之,紫杉醇被认为是一种有效的治疗多药耐药口腔癌。此外,通过解决多药耐药癌细胞的耐药机制,可以有助于药物敏感性的诊断。少
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
田中良治: "Molecular diagnosis of human salivary gland tumors by differential expression of fibroblast growth factor genes."Tissue Culture Res, Commun.. 16. 207-212 (1997)
Ryoji Tanaka:“通过成纤维细胞生长因子基因的差异表达对人类唾液腺肿瘤进行分子诊断。”Tissue Culture Res,Commun.. 16. 207-212 (1997)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
田中良治: "Molecular Diagnosis and Gene Therapy of Salivary Gland Tumors"Int.J.Oral Maxillofac, Surg.. 26. 262 (1997)
Ryoji Tanaka:“唾液腺肿瘤的分子诊断和基因治疗” Int.J.Oral Maxillofac, Surg.. 26. 262 (1997)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
田中 良治: "Molecular Diagnesis and Gene Therapy of Salivary Gland Tumors"Int. J. Oral. Maxillofac. Surg.. 26. 262 (1997)
Ryoji Tanaka:“唾液腺肿瘤的分子诊断和基因治疗”Int. Oral Surg.. 26. 262 (1997)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
田中 良治: "Molecular diaguosis of human salivary glaud tumors by differential explession of fibiblast growth factor genes."Tissue. Culture Res. Commun.. 16. 207-212 (1997)
Ryoji Tanaka:“通过成纤维细胞生长因子基因的差异表达对人唾液腺肿瘤进行分子诊断。”组织培养通讯.. 16. 207-212 (1997)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
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- 通讯作者:
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TANAKA Yoshiharu其他文献
TANAKA Yoshiharu的其他文献
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{{ truncateString('TANAKA Yoshiharu', 18)}}的其他基金
For growth factor-receptor system molecules target, a development study of genetic diagnosis and treatment in oral & maxilla-facial disease
以生长因子-受体系统分子靶点为目标,口腔颌面部疾病基因诊断与治疗的进展研究
- 批准号:
16592001 - 财政年份:2004
- 资助金额:
$ 1.73万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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Apoptosis signal-regulating kinase 1是七氟烷抑制小胶质细胞活化的关键分子靶点?
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