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Ethnopharmacognosical Study on A Southeast Asian Aurantioideae Medicinal Plant Murraya paniculata: Correlation between Its Chemical Diversity and Medicinal Use in Traditional Medicine

东南亚橙科药用植物九里香的民族生药学研究：其化学多样性与传统医学用途的相关性

基本信息

批准号：
12672064
负责人：
KINOSHITA Takeshi
金额：
$ 2.18万
依托单位：
Teikyo University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2002
项目状态：
已结题

项目摘要

A rutaceous medium-size tree "Murraya paniculata " widely occurs in either subtropics or tropics throughout Asia and has found wide medicinal use in this region. This researcher presumed that multivalent uses of this medicinal plant in Asian folk medicine are correlated to diversity of its morphological and chemical properties arising from infra-specific differentiation of the species due to wide phytogeographical distribution, and conducted the corresponding research in order to make clear morphological and chemical diversity of "M paniculata" and hereby reconstruct taxonomy of this species and its allies. Detailed morphological studies on "M paniculata" by inspecting specimens preserved at both Philippine National Museum, Manila, Philippines and Herbarium Bogoriense, Bogor, Indonesia, as well as those prepared from samples collected in Nansei Islands lead to the following conclusions: (1) those occurring in areas extending from Nansei Islands to Taiwan and south mainland China can be … More distinguished as M. exotica based on morphology of leaflets and fruits; (2) what have been considered to be an emdemic variety to Lan Yu, Taiwan, as var. omphalocarpa are morphologically identical to those "occurring in Philippines and its southern neighbors. The synonymity of var. omphalocarpa to the mother species (M. paniculata) was further substantiated by chemical investigation on Philippine species, which revealed that both Philippine and Lan Yu species *re chemically homologous. A comprehensive analysis of prenylcoumarins that have been reported under the name of both M. exotica and M paniculata furnished a hypothesis that they originate biogenetically from the corresponding epoxycoumarins such as sibiricin, gleinadiene epoxide, meranzin and phebalosin, and a group of coumarins arising from each of the above epoxides are expediently designated as A_1 A_2, B_1 and B_2 types, respectively. According to this method, those of Nansei Islands and its vicinity have B_1B_2 type coumarins whereas those of Philippines and its southern neighbors have AB_2 type coumarins, which is in good accordance with results of morphological study. Chemical study on endemic variety (var. zollingeri) occurring in Timor, Indonesia was also conducted and revealed that this variety contains only B2 type coumarins. The uniqueness in chemical property of this variety will be in line with its unique morphological property. About seventy constituents obtained so far from Murraya species were also subjected to various bioassays including anti-oxidant activity in order to clarify whether chemical diversity of this plant furnishes multivalency of use as folk medicine, which were prospected from ethnopharmacognosical viewpoints. Less

草本植物是一种中等大小的草本植物，广泛分布于亚洲的亚热带或热带地区，在这一地区具有广泛的药用价值。本研究推测该药用植物在亚洲民间医学中的多价用途与其因植物地理分布而引起的种下分化而产生的形态和化学性质的多样性有关，并进行了相应的研究，以明确该属的形态和化学多样性，并据此重建该物种及其近缘种的分类学。通过对保存在菲律宾马尼拉国家博物馆和印度尼西亚茂物博高利恩斯植物馆标本以及从南海群岛采集的标本进行详细的形态研究，得出以下结论：(1)从南海群岛到台湾和大陆南部中国的地区发生的这种植物可能是…根据小叶和果的形态更多地区分为M.exotica；(2)已经被认为是对兰屿，台湾的变种的一大变种。黄果树在形态上与“产于菲律宾及其南部邻国”的植物相同。Var的同义词。通过对菲律宾种的化学成分调查，进一步证实了菲律宾种与兰屿种在化学上的同源性。对已报道的异色微囊藻和圆盘微囊藻的戊基香豆素进行了综合分析，提出了它们起源于相应的环氧香豆素的假说，分别命名为A_1、A_2、B_1和B_2型。根据这种方法，南海群岛及其邻近地区含有B_1B_2型香豆素，而菲律宾及其南部邻近地区含有AB_2型香豆素，这与形态研究的结果是一致的。地方性品种(Var.)的化学研究Zollingeri)，并揭示该变种只含有B2型香豆素。该品种在化学性质上的独特性将与其独特的形态特性相一致。从九里香属植物中获得的约70个化学成分也进行了包括抗氧化活性在内的各种生物测定，以澄清该植物的化学多样性是否具有作为民间药用的多价性，从民族药物学的角度对其进行了展望。较少