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Ethnopharmacognosical Study on A Southeast Asian Aurantioideae Medicinal Plant Murraya paniculata: Correlation between Its Chemical Diversity and Medicinal Use in Traditional Medicine

东南亚橙科药用植物九里香的民族生药学研究：其化学多样性与传统医学用途的相关性

基本信息

批准号：
12672064
负责人：
KINOSHITA Takeshi
金额：
$ 2.18万
依托单位：
Teikyo University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2002
项目状态：
已结题

项目摘要

A rutaceous medium-size tree "Murraya paniculata " widely occurs in either subtropics or tropics throughout Asia and has found wide medicinal use in this region. This researcher presumed that multivalent uses of this medicinal plant in Asian folk medicine are correlated to diversity of its morphological and chemical properties arising from infra-specific differentiation of the species due to wide phytogeographical distribution, and conducted the corresponding research in order to make clear morphological and chemical diversity of "M paniculata" and hereby reconstruct taxonomy of this species and its allies. Detailed morphological studies on "M paniculata" by inspecting specimens preserved at both Philippine National Museum, Manila, Philippines and Herbarium Bogoriense, Bogor, Indonesia, as well as those prepared from samples collected in Nansei Islands lead to the following conclusions: (1) those occurring in areas extending from Nansei Islands to Taiwan and south mainland China can be … More distinguished as M. exotica based on morphology of leaflets and fruits; (2) what have been considered to be an emdemic variety to Lan Yu, Taiwan, as var. omphalocarpa are morphologically identical to those "occurring in Philippines and its southern neighbors. The synonymity of var. omphalocarpa to the mother species (M. paniculata) was further substantiated by chemical investigation on Philippine species, which revealed that both Philippine and Lan Yu species *re chemically homologous. A comprehensive analysis of prenylcoumarins that have been reported under the name of both M. exotica and M paniculata furnished a hypothesis that they originate biogenetically from the corresponding epoxycoumarins such as sibiricin, gleinadiene epoxide, meranzin and phebalosin, and a group of coumarins arising from each of the above epoxides are expediently designated as A_1 A_2, B_1 and B_2 types, respectively. According to this method, those of Nansei Islands and its vicinity have B_1B_2 type coumarins whereas those of Philippines and its southern neighbors have AB_2 type coumarins, which is in good accordance with results of morphological study. Chemical study on endemic variety (var. zollingeri) occurring in Timor, Indonesia was also conducted and revealed that this variety contains only B2 type coumarins. The uniqueness in chemical property of this variety will be in line with its unique morphological property. About seventy constituents obtained so far from Murraya species were also subjected to various bioassays including anti-oxidant activity in order to clarify whether chemical diversity of this plant furnishes multivalency of use as folk medicine, which were prospected from ethnopharmacognosical viewpoints. Less

一种芸香中型树木“九里香”广泛分布于整个亚洲的亚热带或热带地区，并在该地区发现了广泛的药用用途。该研究人员推测，这种药用植物在亚洲民间医学中的多价用途与其由于植物地理分布广泛而导致种下分化而导致其形态和化学性质的多样性相关，并进行了相应的研究，以明确“M paniculata”的形态和化学多样性，从而重建该物种及其近缘植物的分类。通过检查保存在菲律宾马尼拉的菲律宾国家博物馆和印度尼西亚茂物茂物植物标本室的标本以及从南西群岛采集的样本制备的标本，对“M panulata”进行了详细的形态学研究，得出以下结论：（1）那些发生在从南西群岛延伸到台湾和中国大陆南部地区的可以与M.paniculata区别开来。基于小叶和果实形态的exotica； (2) 被认为是台湾兰屿的流行品种，如 var.脐果在形态上与菲律宾及其南部邻国出现的相同。通过对菲律宾物种的化学研究进一步证实了变种脐果与母种（M. panulata）的同义性，结果表明菲律宾物种和兰屿物种在化学上是同源的。对以 M. extrica 和兰鱼名称报道的异戊二烯香豆素进行了全面分析。 M panulata提出了一种假设，即它们在生物遗传上源自相应的环氧香豆素，例如西伯利亚星、格莱纳二烯环氧化物、meranzin和苯巴罗辛，并且由上述每种环氧化物产生的一组香豆素分别方便地指定为A_1、A_2、B_1和B_2类型。按照这个方法，南西的岛屿及其附近地区有B_1B_2型香豆素，而菲律宾及其南部邻国则有AB_2型香豆素，这与形态学研究的结果非常吻合。还对印度尼西亚帝汶的特有品种（var. zollingeri）进行了化学研究，结果表明该品种仅含有 B2 型香豆素。该品种化学特性的独特性将符合以其独特的形态特性。迄今为止，从九里香属物种中获得的约 70 种成分也进行了包括抗氧化活性在内的各种生物测定，以澄清该植物的化学多样性是否提供了作为民间药物的多价性，并从民族生药学的角度进行了展望。少