Ethnopharmacognosical Study on A Southeast Asian Aurantioideae Medicinal Plant Murraya paniculata: Correlation between Its Chemical Diversity and Medicinal Use in Traditional Medicine

东南亚橙科药用植物九里香的民族生药学研究：其化学多样性与传统医学用途的相关性

基本信息

批准号：
12672064
负责人：
KINOSHITA Takeshi
金额：
$ 2.18万
依托单位：
Teikyo University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2002
项目状态：
已结题

项目摘要

A rutaceous medium-size tree "Murraya paniculata " widely occurs in either subtropics or tropics throughout Asia and has found wide medicinal use in this region. This researcher presumed that multivalent uses of this medicinal plant in Asian folk medicine are correlated to diversity of its morphological and chemical properties arising from infra-specific differentiation of the species due to wide phytogeographical distribution, and conducted the corresponding research in order to make clear morphological and chemical diversity of "M paniculata" and hereby reconstruct taxonomy of this species and its allies. Detailed morphological studies on "M paniculata" by inspecting specimens preserved at both Philippine National Museum, Manila, Philippines and Herbarium Bogoriense, Bogor, Indonesia, as well as those prepared from samples collected in Nansei Islands lead to the following conclusions: (1) those occurring in areas extending from Nansei Islands to Taiwan and south mainland China can be … More distinguished as M. exotica based on morphology of leaflets and fruits; (2) what have been considered to be an emdemic variety to Lan Yu, Taiwan, as var. omphalocarpa are morphologically identical to those "occurring in Philippines and its southern neighbors. The synonymity of var. omphalocarpa to the mother species (M. paniculata) was further substantiated by chemical investigation on Philippine species, which revealed that both Philippine and Lan Yu species *re chemically homologous. A comprehensive analysis of prenylcoumarins that have been reported under the name of both M. exotica and M paniculata furnished a hypothesis that they originate biogenetically from the corresponding epoxycoumarins such as sibiricin, gleinadiene epoxide, meranzin and phebalosin, and a group of coumarins arising from each of the above epoxides are expediently designated as A_1 A_2, B_1 and B_2 types, respectively. According to this method, those of Nansei Islands and its vicinity have B_1B_2 type coumarins whereas those of Philippines and its southern neighbors have AB_2 type coumarins, which is in good accordance with results of morphological study. Chemical study on endemic variety (var. zollingeri) occurring in Timor, Indonesia was also conducted and revealed that this variety contains only B2 type coumarins. The uniqueness in chemical property of this variety will be in line with its unique morphological property. About seventy constituents obtained so far from Murraya species were also subjected to various bioassays including anti-oxidant activity in order to clarify whether chemical diversity of this plant furnishes multivalency of use as folk medicine, which were prospected from ethnopharmacognosical viewpoints. Less

在亚洲各地的亚热带或热带地区，肉眼的中型树“ Murraya Paniculata”广泛发生，并在该地区发现了广泛的医疗用途。这位研究人员被认为是，该医疗植物在亚洲民间医学中的多价使用与其形态和化学特性的多样性相关，这是由于广泛的地理分布而引起的该物种的非特异性分化，并进行了相应的研究，以便使“ M Paniculata”和此处重新构造的“ M Paniculata”的形态和化学多样性和化学多样性和化学分类的分类法和该物种的分类法和该物种的分类法和该物种的分类范围。通过检查在菲律宾国家博物馆，马尼拉，菲律宾，菲律宾和印度尼西亚鲍哥的植物标本室的菲律宾国家博物馆，印度尼西亚，印度尼西亚的菲律宾国家博物馆以及从南西群岛收集的样品中准备的样本，详细介绍了以下结论：基于传单和水果的形态的异国情调；（2）被认为是台湾Lan Yu的流行性品种。杂波果在形态上与“发生在菲律宾及其南部邻国发生的人相同。对母种的同义词（M. paniculata）的同义词进一步证实了对菲律宾物种的化学投资，这是菲律宾物种的化学投资，这表明菲利普（Philippine and Lan Yu）均表明，在菲律宾物种上均已据报道。 Paniculata提供了一种假设，即它们以相应的环氧酸乳蛋白（例如sibiricin，gleinadiene epoxide，meranzin和phebalosin）以及一组由上述环氧化物产生的香豆素为A_1 A_1 A_1 A_2，B_1和b_2类型，从而相应地相应地指定为A_1 A_1 a_1 a_1和b_2，它们是相应的，它们是相应的，它们是根据n anan的，它们是相应的，它们属于b_1和b_2和b_2类型。附近具有B_1B_2型Comarins，而菲律宾及其南部邻居的AB_2型Comarins则根据形态学研究的结果很好。 Zollingeri）发生在帝汶，印度尼西亚也进行了，并揭示了该品种仅包含B2型Comarins。该品种的化学特性的独特性将符合其独特的形态特性。从穆雷拉物种到远处获得的大约70个构成也受到了各种生物测定，包括抗氧化活性，以澄清该植物的化学多样性是否提供了多种用作民间医学的用途，这是从民族药物认知观点所期望的。较少的