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Ethnopharmacognosical Study on A Southeast Asian Aurantioideae Medicinal Plant Murraya paniculata: Correlation between Its Chemical Diversity and Medicinal Use in Traditional Medicine

东南亚橙科药用植物九里香的民族生药学研究：其化学多样性与传统医学用途的相关性

基本信息

批准号：
12672064
负责人：
KINOSHITA Takeshi
金额：
$ 2.18万
依托单位：
Teikyo University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2002
项目状态：
已结题

项目摘要

A rutaceous medium-size tree "Murraya paniculata " widely occurs in either subtropics or tropics throughout Asia and has found wide medicinal use in this region. This researcher presumed that multivalent uses of this medicinal plant in Asian folk medicine are correlated to diversity of its morphological and chemical properties arising from infra-specific differentiation of the species due to wide phytogeographical distribution, and conducted the corresponding research in order to make clear morphological and chemical diversity of "M paniculata" and hereby reconstruct taxonomy of this species and its allies. Detailed morphological studies on "M paniculata" by inspecting specimens preserved at both Philippine National Museum, Manila, Philippines and Herbarium Bogoriense, Bogor, Indonesia, as well as those prepared from samples collected in Nansei Islands lead to the following conclusions: (1) those occurring in areas extending from Nansei Islands to Taiwan and south mainland China can be … More distinguished as M. exotica based on morphology of leaflets and fruits; (2) what have been considered to be an emdemic variety to Lan Yu, Taiwan, as var. omphalocarpa are morphologically identical to those "occurring in Philippines and its southern neighbors. The synonymity of var. omphalocarpa to the mother species (M. paniculata) was further substantiated by chemical investigation on Philippine species, which revealed that both Philippine and Lan Yu species *re chemically homologous. A comprehensive analysis of prenylcoumarins that have been reported under the name of both M. exotica and M paniculata furnished a hypothesis that they originate biogenetically from the corresponding epoxycoumarins such as sibiricin, gleinadiene epoxide, meranzin and phebalosin, and a group of coumarins arising from each of the above epoxides are expediently designated as A_1 A_2, B_1 and B_2 types, respectively. According to this method, those of Nansei Islands and its vicinity have B_1B_2 type coumarins whereas those of Philippines and its southern neighbors have AB_2 type coumarins, which is in good accordance with results of morphological study. Chemical study on endemic variety (var. zollingeri) occurring in Timor, Indonesia was also conducted and revealed that this variety contains only B2 type coumarins. The uniqueness in chemical property of this variety will be in line with its unique morphological property. About seventy constituents obtained so far from Murraya species were also subjected to various bioassays including anti-oxidant activity in order to clarify whether chemical diversity of this plant furnishes multivalency of use as folk medicine, which were prospected from ethnopharmacognosical viewpoints. Less

九里香是一种芸香科中型乔木，广泛分布于亚洲的亚热带或热带地区，在该地区有广泛的药用价值。本研究推测，该药用植物在亚洲民间医药中的多价用途与其广泛的植物地理分布引起的种下分化所导致的形态和化学性质的多样性有关，并进行了相应的研究，以明确“M paniculata”的形态和化学多样性，并据此重建该种及其近缘种的分类。通过对菲律宾国家博物馆和印度尼西亚博戈尔植物标本馆保存的“M paniculata”标本以及南西群岛采集的标本的形态学研究，得出以下结论：（1）从南西群岛到台湾和中国大陆南部的地区，可能存在着“M paniculata”，但其形态学特征可能与“M paniculata”有关。 ...更多信息区别为M.根据小叶和果实的形态学特征，可以推测为外来种;（2）台湾兰屿的特有种，如var.在形态上与那些“发生在菲律宾及其南部邻国的”相同。var的synchronity。omalescarpa对母种（M.通过对菲律宾种的化学研究，进一步证实了菲律宾种与兰屿种在化学上具有同源性。对已报道的以M. exotica和M. paniculata提出了它们的生物起源是由相应的环氧香豆素类化合物sibiricin、gleinadiene epoxide、meranzin和phebalosin等衍生而来的假说，并将它们分别命名为A_1、A_2、B_1和B_2型。根据这种方法，南西群岛及其邻近海域的香豆素为B_1B_2型，而菲律宾及其南部邻国的香豆素为AB_2型，这与形态学研究结果相一致。特有变种的化学研究。zollingeri），发现该品种仅含有B2型香豆素。该品种化学性质的独特性与其独特的形态特征相一致。从九里香属植物中提取了约70种化合物，并对其进行了抗氧化活性等生物活性测定，以明确九里香的化学多样性是否具有作为民间药物的多价性，并从民族药理学的角度进行了展望。少