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Effects of non-digestible fibers on the osteoporosis

不可消化纤维对骨质疏松症的影响

基本信息

批准号：
12680137
负责人：
YAMAMOTO Yukiko
金额：
$ 2.18万
依托单位：
Osaka City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

项目摘要

The effects of dietary addition of pectin or pullulan on the Ca absorption in gastroinstestinal tract and bone mineral contents in rats were studied. Three weeks male Sprague-Dawley rats were separated in three groups and were fed diets (Ca, 0.3%) containing 5% of cellulose, pectin, or pullulan for 8 weeks. The Ca concentration in plasma, amount of Ca ingested, and Ca excreted in feces, and Ca absorption were not affected by dietary pectin or pullulan. Also, dry weight and length of femur and ash, Ca and P contents in it, osteocalcin concentration in plasma, and the amount of pyridinoline excreted in urine were not affected by dietary addition of pectin or pullulan. These results suggested that pectin and pullulan are not effective on Ca absorption and bone mineral contents.The effects of dietary addition of onion on the Ca absorption in gastroinstestinal tract and bone mineral contents in rats were also studied. Male Sprague-Dawley rats were separated in four groups and were fed diets containing 5% of cellulose, whole onion, waterssoluble fraction of onion, or water-insoluble fraction of onion for 8 weeks. The Ca concentration in plasma, amount of Ca ingested, and Ca excreted in feces, and Ca absorption were not affected by dietary onion. Also, dry weight and length of femur and ash, and the amount of pyridinoline excreted in urine were not affected by dietary addition of onion. The Ca and P contents in femur were increased by the addition of onion. The osteocalcin concentration in plasma was increased by die addition of onion. These results suggested that onion might be effective on the increase in the bone formation and then bone mineral contents. The effects of onion on the bone formation in the osteoblastic cells were studied. Quercetin was effective to enhance the Alkaline phospatase activity and to increase Ca contents in the cells.These results of in vivo and in vitro experiments suggested that dietary onion might be effective on the bone formation.

研究了日粮中添加果胶或普鲁兰对大鼠胃肠道钙吸收及骨矿物质含量的影响。将3周龄雄性Sprague-Dawley大鼠分为3组，分别饲喂含有5%纤维素、果胶或普鲁兰的饲粮（Ca, 0.3%） 8周。饲粮中果胶和普鲁兰对血浆钙浓度、钙摄取量、粪便钙排泄量和钙吸收量均无影响。饲粮中添加果胶和普鲁兰对股骨和灰分的干重、干长、钙、磷含量、血浆骨钙素浓度和尿中吡啶啉的排泄量均无显著影响。由此可见，果胶和普鲁兰对钙吸收和骨矿物质含量影响不大。研究了日粮中添加洋葱对大鼠胃肠道钙吸收及骨矿物质含量的影响。雄性Sprague-Dawley大鼠分为4组，分别饲喂含5%纤维素、全洋葱、洋葱水溶性部分和洋葱不水溶性部分的饲粮，为期8周。饲粮洋葱对血浆钙浓度、钙摄取量、粪便钙排泄量及钙吸收量均无影响。饲粮中添加洋葱对大腿骨和灰分的干重、干长以及尿中吡啶的排泄量没有影响。添加洋葱可提高股骨钙、磷含量。添加洋葱可提高血浆骨钙素浓度。这些结果表明，洋葱可能对骨形成和骨矿物质含量的增加有效。研究了洋葱对成骨细胞成骨的影响。槲皮素能有效提高细胞碱性磷酸酶活性，提高细胞钙含量。这些体内和体外实验结果表明，食用洋葱可能对骨形成有影响。