课题基金 / 基金详情

Methylsulfonyl metabolites of polychlorinated biphenyl and polybrominated biphenyl as disrupters of endocrine action

Methylsulfonyl metabolites of polychlorinated biphenyl and polybrominated biphenyl as disrupters of endocrine action
多氯联苯和多溴联苯的甲磺酰代谢物作为内分泌作用的干扰物
批准号:
12680549
负责人:
KATO Yoshihisa
金额:
$2.43万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2000
资助国家:
日本
项目状态:
已结题
起止时间:
2000 至 2002

项目摘要

项目成果

KATO Yoshihisa的其他基金

相似基金

相关文献

中文摘要
翻译
1.本研究结果表明,3-甲磺酰基-2,2‘,4’,5-四溴联苯(3-Meso_2-TetraBrB)对药物代谢酶的影响比母体TetraBrB或苯巴比妥高几千倍,而其同分异构体4-Meso_2-TetraBrB的作用不明显。这些结果表明,3-Meso_2-TetraBrB在TetraBrB诱导微粒体药物代谢酶中起重要作用。目前的研究结果表明,1,3-二氯苯(DCB)、1,2,4-三氯苯以及四、五和六氯联苯的9种Meso_2代谢物可降低大鼠的甲状腺激素水平,提示这些代谢物可能是内分泌干扰物。上述结果提示,8种MesO_2-多氯联苯和3,5-二氯苯甲基砜均可引起小鼠血清T_4水平下降,可能是由于UGT1A1和UGT1A6的共同诱导,导致了肝脏T_4葡萄糖醛酸化作用的增强。DCB-,2,2‘,4’,5,5‘-五氯联苯、2,2’,3‘,4’,5,6-六氯联苯(HexaCB-)和Kanechlor500-(KC500-)处理的小鼠、仓鼠、大鼠和豚鼠的肝脏Meso_2代谢物浓度的差异与血清总T_4水平的下降无关。上述结果提示,DCB、HexaCB和KC500对大鼠、小鼠和豚鼠血清总T_4水平的降低作用至少部分是通过诱导肝T_4-UDP-葡萄糖醛酸基转移酶(T_4-UDP-GT),尤其是UGT1A1和UGT1A6诱导T_4葡萄糖醛酸化作用来实现的,而对小鼠、金黄地鼠和大鼠血清总T_4水平的降低可能是通过其他机制实现的。
英文摘要
1. The results from the present study show that the effects of 3-methylsulfonyl-2, 2', 4', 5-tetrabromobiphenyl (3-MeSO_2-TetraBrB) on the drug-metabolizing enzymes, CYP2B1 and CYP2B2, are several thousand-fold higher than those of parent TetraBrB or phenobarbital, while the effects of its isomeric 4-MeSO_2-TetraBrB are not.2. The present results suggest that 3-MeSO_2-TetraBrB plays an important role in the induction of microsomal drug-metabolizing enzymes by TetraBrB.3. The present findings show that the nine MeSO_2 metabolites of 1, 3-dichlorobenzene (DCB), 1, 2, 4-trichloro-benzene, and tetra-, penta- and hexachlorobiphenyls reduce thyroid hormone levels in rats, suggesting that the metabolites may act as endocrine-disrupters.4. The present results indicate that increase in the hepatic thyroxine (T_4) glucuronidation after the administration of the eight MeSO_2-polychlorinated biphenyls and 3, 5-dichlorophenyl methyl sulfone possibly because of the induction of both UGT1A1 and UGT1A6 caused the reduction of serum T_4 levels.5. The difference in total hepatic concentration of MeSO_2 metabolites among DCB-, 2, 2', 4', 5, 5'-pentachlorobiphenyl-(PentaCB-), 2, 2', 3', 4', 5, 6-hexachlorobiphenyl- (HexaCB-) and Kanechlor-500- (KC500-) treated mice, hamsters, tats and guinea pigs was not correlated with that in the decrease in serum total T_4 level.6. The present findings suggest that the reduction of serum total T_4 level by DCB, HexaCB and KC500 in rats, mice and guines pigs, respectively, would occur at least in part by an increase in T_4 glucuronidation through the induction of hepatic T_4-UDP-glucuronosyltransferase (T_4-UDP-GT), especially UGT1A1 and UGT1A6, while the decrease of serum total T_4 level by PentaCB, TetraBrB and KC500 in mice, hamsters and rats may occur through alternative mechanisms.
期刊论文(47)
专著(0)
科研奖励(0)
会议论文
Yoshihisa Kato: "In vivo metabolism of 2,2',4',5,5'-pentachlorobiphenyl and its inductive activity of drug-metabolizing enzymes : Species difference between rats and mice"Organohalogen Compounds. 49. 213-216 (2000)
加藤嘉久:“2,2,4,5,5-五氯联苯的体内代谢及其药物代谢酶的诱导活性:大鼠和小鼠之间的物种差异”有机卤素化合物。
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Yoshihisa Kato.: "Effects of polychlorinated biphenyls (Kanechlor-500) on serum hormone levels in rats and mice"Organohalogen Compounds. 53. 47-49 (2001)
Yoshihisa Kato.:“多氯联苯 (Kanechlor-500) 对大鼠和小鼠血清激素水平的影响”有机卤素化合物。
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Yoshihisa Kato: "Reduction of serum thyroxine concentration by methylsulfonyl metabolites of chlorobenzenes in male rats"J.Toxicol.Sci.. 26. 241 (2001)
加藤嘉久:“雄性大鼠中氯苯甲磺酰代谢物降低血清甲状腺素浓度”J.Toxicol.Sci.. 26. 241 (2001)
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Yoshihisa Kato: "3 -Methylsulfonyl-2,2',4',5 -tetrabromobiphenyl, a metabolite of 2,2',4',5-tetrabromobiphenyl induces CYP2B1/2 in rats"Organohalogen Compounds. 49. 209-212 (2000)
Yoshihisa Kato:“3-甲基磺酰基-2,2,4,5-四溴联苯,2,2,4,5-四溴联苯的代谢物在大鼠中诱导 CYP2B1/2”有机卤素化合物。
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
38
    Elucidation of the mechanism for the chemical substances such as polychlorinated biphenyls induced decrease in the serum thyroxine level
    • 批准号:
      18K11660
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2018
    • 负责人:
      KATO Yoshihisa
    • 依托单位:
    Study on the exact mechanism for the polychlorinated biphenyl-induced decrease in the serum thyroxine level
    • 批准号:
      23510083
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.49万
    • 财政年份:
      2011
    • 负责人:
      KATO Yoshihisa
    • 依托单位:
    Chemical oceanographic section study of dissolved barium in the western Indian Ocean
    • 批准号:
      22510018
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.66万
    • 财政年份:
      2010
    • 负责人:
      KATO Yoshihisa
    • 依托单位:
    Latitudinal section mapping of pore water constituents in the central and eastern equatorial Pacific
    • 批准号:
      19510014
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2007
    • 负责人:
      KATO Yoshihisa
    • 依托单位:
    海外基金