Self organization of the bioactive polysaccharide derivatives

点击翻译按钮获取中文摘要

Chitosan is a polysaccharide having various biological activities. The hydrophobized chitosan derivatives are expected to form self aggregates in aqueous solution. Such an aggregation of bioactive polymers are useful for biomaterials. In this study, we have synthesized new hydrophobized chitosan derivatives branched cholesterol or dehydroabietylamine moieties as a side chain to the amino group of chitosan. The self aggregation of he chitosan derivatives were studied by the fluorescence probe method. The results suggested the cholesterol-chitosan derivative formed micelle-like aggregation, while the dehydroabietylamine-chitosan derivative aggregated randomly. Furthermore, we have developed the one-pot introduction of N-benzyl side chains to chitosan using by a Mannich reaction.