Self organization of the bioactive polysaccharide derivatives

生物活性多糖衍生物的自组织

• 批准号: 12680831
• 负责人: SHIGEMASA Yoshihiro
• 金额: $ 1.66万
• 依托单位: Tottori University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12680831/
• 关键词: Chitosan; Biolactivity; Self organization; Chitosan derivative; Glycolchitosan; Micelle; Phenolic compound; Mannich reaction; 会合体; コレステロール; デヒドロアビエチル; 両親媒性多糖; 乳化安定化; Mannich reaction; 構造制御; 疎水性置換基; ミセル形成; 蛍光プローブ

Chitosan is a polysaccharide having various biological activities. The hydrophobized chitosan derivatives are expected to form self aggregates in aqueous solution. Such an aggregation of bioactive polymers are useful for biomaterials. In this study, we have synthesized new hydrophobized chitosan derivatives branched cholesterol or dehydroabietylamine moieties as a side chain to the amino group of chitosan. The self aggregation of he chitosan derivatives were studied by the fluorescence probe method. The results suggested the cholesterol-chitosan derivative formed micelle-like aggregation, while the dehydroabietylamine-chitosan derivative aggregated randomly. Furthermore, we have developed the one-pot introduction of N-benzyl side chains to chitosan using by a Mannich reaction.

壳聚糖是一种具有多种生物活性的多糖。疏水化壳聚糖衍生物在水溶液中有望形成自聚集体。这种生物活性聚合物的聚集体可用于生物材料。在这项研究中，我们合成了新型疏水化壳聚糖衍生物，支化胆固醇或脱氢枞胺部分作为壳聚糖氨基的侧链。用荧光探针法研究了壳聚糖衍生物的自聚集行为。结果表明，胆固醇-壳聚糖衍生物形成了胶束状聚集体，而脱氢松香胺-壳聚糖衍生物形成了无规聚集体。此外，我们开发了一锅引入N-苄基侧链壳聚糖使用的曼尼希反应。

项目成果

Y.Omura et al.: "Regioselective Mannich reaction of phenolic compounds and its application to the synthesis of new chiotsan derivatives"Tetrahedron Letters. 42. 7273-7275 (2001)

Y.Omura等：“酚类化合物的区域选择性曼尼希反应及其在新型壳聚糖衍生物合成中的应用”Tetrahedron Letters。

X.Li et al.: "Biological Activity of Chitosan-Sugar Hybrids : Specific Interaction with Lectin"Polymer for Advanced Technology. 11. 176-179 (2000)

X.Li 等人：“壳聚糖-糖杂化物的生物活性：与凝集素的特异性相互作用”聚合物的先进技术。

X. Li et al.: "Biological Activity of Chitosan-Sugar Hybrids : Specific Interaction with Lectin"Polymer for Advanced Technology. 11. 176-179 (2000)

X. Li 等人：“壳聚糖-糖杂化物的生物活性：与凝集素的特异性相互作用”聚合物的先进技术。

Y. Omura et al.: "Regioselective Mannich reaction of phenolic compounds and its application to the synthesis of new chitosan derivatives"Tetrahedron Letters. 42. 7273-7275 (2001)

Y. Omura等：“酚类化合物的区域选择性曼尼希反应及其在新型壳聚糖衍生物合成中的应用”Tetrahedron Letters。

M.Morimoto et al.: "Biological Activities of Carbohydrate-Branched Chitosan Derivatives"Biomacromolecules. 2. 1133-1136 (2001)

M.Morimoto等人：“碳水化合物支链壳聚糖衍生物的生物活性”生物大分子。