Research on improvement of radioactivity quantitation in the human body in thallium-201 scintigraphic imaging study

铊201闪烁显像研究中人体放射性定量的改进研究

• 批准号: 12680838
• 负责人: KOJIMA Akihiro
• 金额: $ 1.15万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12680838/
• 关键词: thallium-201 imaging; radioactivity quantitation; computer simulation; scatter correction; attenuation correction; gamma camera; myocardial phantom experiment; SPECT; タリウム201; 核医学イメージング; 透過型減弱補正; コンピュータシミュレーション; エネルギー解析; ファントム実験

In the nuclear medicine study, it is very important to accurately estimate radioactivity distribution in the human body for reliable diagnosis with scintigraphic images. In this study, we investigated it about improvement of radioactivity quantitation in the human body in thallium-201 (Tl-201) scintigraphic imaging.First, we simulated the photons emitted from Tl-201 in a phantom using Monte Carlo programs and a personal computer, and analyzed energy distributions for photons detected outside the phantom in detail. From the amount of non-scattered with true emission location information and scattered photons with false emission location information contained within the imaging window, we could develop a scatter correction method. Next, we performed Tl-201 planar imaging of a simple phantom using a gamma camera and applied this scatter correction method for the images acquired. The results showed that this scatter correction method can distinguish non-scattered photons from scattered photons more accurately and effectively in comparison with the conventional ones. In addition, to investigate how both scatter arid attenuation corrections can quantitatively improve SPECT values, Tl-201 myocardial SPECT imaging was performed using a dual-head gamma camera SPECT system and a sophisticated phantom. The attenuation correction method which was developed with the joint researchers in this project was employed. From the results of this myocardial SPECT experiments, in order to improve quantitative SPECT value in the myocardial imaging, it became clear to be important to apply the attenuation correction to accurately scatter-corrected SPECT images.We consider that our results from this research may be very useful to clinical Tl-201 myocardial imaging with more accurate diagnostic information.

在核医学研究中，准确估计人体内放射性分布对于利用放射性成像图像进行可靠的诊断是非常重要的。本研究旨在探讨改善铊-201（Tl-201）放射性成像中人体放射性定量的方法，首先利用Monte Carlo程序和个人计算机模拟了Tl-201在体模中发射的光子，并详细分析了体模外探测到的光子的能量分布。从成像窗口内包含的具有真实发射位置信息的非散射光子和具有虚假发射位置信息的散射光子的量，我们可以开发散射校正方法。接下来，我们使用伽马照相机对简单体模进行Tl-201平面成像，并将该散射校正方法应用于所采集的图像。结果表明，与传统的散射校正方法相比，该方法能更准确、有效地区分非散射光子和散射光子。此外，为了研究散射和衰减校正如何定量改善SPECT值，使用双头伽马相机SPECT系统和复杂的体模进行了Tl-201心肌SPECT成像。采用了与本项目联合研究人员共同开发的衰减校正方法。从本实验的结果来看，为了提高心肌显像的定量SPECT价值，对散射校正后的SPECT图像进行衰减校正是非常重要的，我们认为本研究的结果对临床Tl-201心肌显像有很大的帮助，可以提供更准确的诊断信息。